STEPHEN LOUIS ECK
Medical Practice in Ann Arbor, MI
License number
Pennsylvania MD049378L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Ann Arbor, MI 48103
Pennsylvania
Pennsylvania
Personal information
See more information about STEPHEN LOUIS ECK at radaris.comName
Address
Phone
1247 Rose Valley Rd, Cogan Station, PA 17728
855 Maple Spring Rd APT D, Linden, PA 17744
541 Sunset Dr, Linden, PA 17744
482 Tiadaghton Trl, Jersey Shore, PA 17740
421 S Broad St, Jersey Shore, PA 17740
Professional information
Combinations Of Signal Transduction Inhibitors
US Patent:
2005022, Oct 6, 2005
Filed:
Mar 30, 2005
Appl. No.:
11/095442
Inventors:
Stephen Eck - Ann Arbor MI, US
David Fry - Ypsilanti MI, US
Judith Leopold - Ann Arbor MI, US
David Fry - Ypsilanti MI, US
Judith Leopold - Ann Arbor MI, US
International Classification:
A61K031/519
US Classification:
514252160
Abstract:
The present invention relates to methods for treating cancer comprising utilizing a combination of signal transduction inhibitors. More specifically, the present invention relates to combinations of so called cell cycle inhibitors with mitogen stimulated kinase signal transduction inhibitors, more specifically combinations of CDK inhibitors with mitogen stimulated kinase signal transduction inhibitors, more preferably MEK inhibitors. Other embodiments of the invention relate to additional combinations of the aforesaid combinations with standard anti-cancer agents such as cytotoxic agents, palliatives and antiangiogenics. Most specifically this invention relates to combinations of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one including salt forms, which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor, in combination with one or more MEK inhibitors, most preferably N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide. The aforementioned combinations are useful for treating inflammation and cell proliferative diseases such as cancer and restenosis.