Inventors:
Kim Lee Sim - Rockville MD, US
Stephen Hoffman - Rockville MD, US
Myriam Arevalo - Cali, CO
Socrates Herrera - Cali, CO
International Classification:
A61K 39/00, A61K 39/38, A01N 43/04, C07H 21/02, C07H 21/04
US Classification:
4242691, 4241841, 514 44, 536 231, 536 237
Abstract:
Malaria in humans is caused by infection with species parasites including. The biology and immunobilogy of is distinct from that of. Provided are unique synthetic polypeptides and DNA molecules which encode them. Each of these molecules correspond to regions of the circumsporozoite protein of. Each molecule comprises sequences corresponding to several repeats of the central region of the Pv 210 variant fused to sequences corresponding to several repeats of the central region of the Pv 247 variant. Each molecule additionally comprises sequences corresponding to either the amino terminus, the carboxy terminus, or both the amino and carboxy termini of the PvCSP. Also provided are vaccines comprising these unique sequences and methods of using these vaccines and sequences to prevent and treat Pv malaria.