STEPHEN L TROKEL, M.D.
Medical Practice at 165 St, New York, NY

5711762, Jan 27, 1998

Jun 7, 1995

8/474243

Stephen Trokel - New York NY

Visx, Incorporated - Sunnyvale CA

A61N 503

606 5

An argon-fluoride excimer laser or other laser source capable of generating far-ultraviolet radiation at 193 nm is pulsed with energy densities of greater than 20 mj per cm. sup. 2 at a repetition rate up to 25 pulses per second to direct its radiation through a mask and onto corneal tissue, or other biological matter, to form an ablation therein of predetermined configuration and depth by a process of ablative photodecomposition. The masks are formed with a slit, circular, crescent or other openings of widths between 30 and 800 microns, and may even be formed to provide a graded intensity center to edge. The mask is reflective or composed of or faced with an organic polymer to prevent heat build-up. Each micron of the depth of a 200 micron deep groove formed in corneal tissue, for example, resulted from the application of 1 joule per square centimeter of radiation, from a series of pulses delivered at intensities of between 100 mj and 200 mj per square centimeter, and at a laser pulse rate of between 1 and 25 Hertz, the entire groove taking 100 seconds.

5735843, Apr 7, 1998

Jun 7, 1995

8/480243

Stephen Trokel - New York NY

VISX, Incorporated - Santa Clara CA

A61N 506

606 5

An argon-fluoride excimer laser or other laser source capable of generating far-ultraviolet radiation at 193 nm is pulsed with energy densities of greater than 20 mj per cm. sup. 2 at a repetition rate up to 25 pulses per second to direct its radiation through a mask and onto corneal tissue, or other biological matter, to form an ablation therein of predetermined configuration and depth by a process of ablative photodecomposition. The masks are formed with a slit, circular, crescent or other openings of widths between 30 and 800 microns, and may even be formed to provide a graded intensity center to edge. The mask is reflective or composed of or faced with an organic polymer to prevent heat build-up. Each micron of the depth of a 200 micron deep groove formed in corneal tissue, for example, resulted from the application of 1 joule per square centimeter of radiation, from a series of pulses delivered at intensities of between 100 mj and 200 mj per square centimeter, and at a laser pulse rate of between 1 and 25 Hertz, the entire groove taking 100 seconds.

5108388, Apr 28, 1992

Oct 16, 1987

7/109812

Stephen L. Trokel - New York NY

Visx, Incorporated - Sunnyvale CA

A61N 506

606 5

An argon-flouride excimer laser or other laser source capable of generating far-ultraviolet radiation at 193 nm is pulsed with energy densities of greater than 20 mj per cm. sup. 2 at a repetition rate up to 25 pulses per second to direct its radiation through a mask and onto corneal tissue, or other biological matter, to form a groove therein of predetermined configuration and depth by a process of ablative photodecomposition. The masks are formed with a slit, circular, crescent or other openings of widths between 30 and 800 microns, and may even be formed to provide a graded intensity center to edge. The mask is reflective or composed of or faced with an organic polymer to prevent heat build-up. Each micron of the depth of a 200 micron deep groove formed in corneal tissue, for example, resulted from the application of 1 joule per square centimeter of radiation, from a series of pulses delivered at intensities of between 100 mj and 200 mj per square centimeter and at a laser pulse rate of between 1 and 25 Hertz; the entire groove taking 100 seconds.

2012028, Nov 15, 2012

May 18, 2012

13/475175

David Muller - Boston MA, US
John Marshall - Farnborough, GB
Stephen L. Trokel - New York NY, US
Peter Hersh - Far Hills NJ, US
Pavel Kamaev - Lexington MA, US

Avedro, Inc. - Waltham MA

A61M 37/00

604 20

Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.

8466203, Jun 18, 2013

Dec 6, 2007

12/517382

David Choohyun Paik - Cheltenham PA, US
Stephen Lewis Trokel - New York NY, US

A01N 59/00, A01N 33/18, A01N 33/24, A61K 33/00, A61K 31/045, C12N 5/00, C12N 5/02

514727

A method for stabilizing collagenous eye tissues by nitrite and nitroalcohol treatment. The topical stiffening agent contains sodium nitrite or a nitroalcohol in a buffered balanced salt solution and can be applied to the surface of the eye on a daily basis for a prolonged period. Application of the solution results in progressive stabilization of the corneal and scleral tissues through non-enzymatic cross-linking of collagen fibers. The compounds can penetrate into the corneal stroma without the need to remove the corneal epithelium. In addition, ultraviolet light is not needed to activate the cross-linking process. The resulting stabilization of corneal and scleral tissues can prevent future alterations in corneal curvature and has utility in diseases such as keratoconus, keratectasia, progressive myopia, and glaucoma.

4988163, Jan 29, 1991

Aug 17, 1989

7/395342

Martin G. Cohen - Northport NY
William I. Kern - Smithtown NY
Stephen Trokel - New York NY

Quantronix Corp. - Smithtown NY

G02B 602, G02B 616, A61B 100

350 9629

A low energy laser system for surgical purposes, in particular, ophthalmic surgery, comprises a source of pulsed laser energy. Er:YAG lasers having a wavelength of 3 microns are preferred. Optical fibers which are responsive to the laser energy deliver amounts of the laser energy to selected body tissue sufficient to perform delicate surgical procedures without adverse biological or chemical interaction with the tissue. In particular, a compound fiber assembly is preferred for delivery of laser energy having a wavelength above 2 microns which compound fiber comprises an elongated fiber body comprised of fluoride based glass, a surgical optical fiber tip of a hard, moderately transparent mineral, such as quartz or sapphire, and an element for coupling the optical fiber tip to the fluoride glass body.

4052985, Oct 11, 1977

Jun 28, 1976

5/700481

D. Jackson Coleman - Haworth NJ
Stephen L. Trokel - New York NY

A61M 1100

128173R

An apparatus for administering a fine mist of an ophthalmic solution to the eyeball of a human. The apparatus is a spray applicator which features the provision of a baffle in the lower portion of an eyecup. The baffle is spaced from the inner surface of the eyecup, with the lateral ends or the entire lower periphery of the baffle being attached to the inner surface of the eyecup. A container such as an aerosol can or plastic squeeze bottle holding the ophthalmic solution is provided, together with ancillary elements to transmit the solution, so that the ophthalmic solution can be projected at will, i. e. when the eyecup is emplaced over an eyeball, into the lower portion of the eyecup opposite the baffle, so that the solution impinges on the baffle rather than directly impinging on the eyeball, the solution thus being effectively dispersed into a mist of small droplets within the eyecup, which mist thus uniformly and gently coats the outer surface of the eyeball. The central portion of the eyecup is preferably composed of a material such as glass, plexiglass or lucite which transmits light, i. e. the central portion of the eyecup is translucent or transparent.

2011028, Nov 24, 2011

Apr 13, 2011

13/086019

David Muller - Boston MA, US
John Marshall - Farnborough, GB
Stephen L. Trokel - New York NY, US
Peter Hersh - Far Hills NJ, US
Pavel Kamaev - Lexington MA, US

AVEDRO, INC. - Waltham MA

A61M 37/00

604 20, 604 22, 604521

Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.

4638801, Jan 27, 1987

Oct 23, 1985

6/790637

Richard T. Daly - Huntington NY
Stephen L. Trokel - New York NY

Lasers for Medicine - Hauppauge NY

A61B 1736

1283031

An ophthalmic slit lamp is modified by adding a laser to it to be used for microsurgery. The laser is mounted on the lamp so its beam is projected into the eye along one axis while the normal viewing image generated by the lamp is focused into the eye from another angle. An aiming image is focused into the eye coincidentally with the laser beam so that the distance between the two images and their relative position may be determined by their apparent positions as seen from the viewing binoculars of the lamp.