Inventors:
Stephen C. Johnson - Birmingham AL, US
Ashraf Saeed - Birmingham AL, US
Ming Luo - Birmingham AL, US
Assignee:
IBBEX, Inc. - Birmingham AL
Univ. of Alabama at Birmingham - Birmingham AL
International Classification:
C07H 1504, C07H 1704
US Classification:
51425409, 514307, 514314, 514339, 514374, 514422, 514432, 514538, 424 165, 435 18, 536 172, 536 173, 536 174, 536 177, 536 178, 536 179, 536 181, 536 184
Abstract:
The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. These compounds are based upon N-acetylneuraminic acid glycosides. In particular, this invention provides a novel class of these compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.