Stephen Jack Herman
Engineers at Sunset Rock Rd, Andover, MA

6350463, Feb 26, 2002

May 21, 1999

09/316879

Stephen J. Herman - Andover MA
Glenn M. Kazo - New Ipswich NH
David J. Enscore - Sudbury MA
J. Jeffrey Kablik - Tyngsboro MA

Andre Bieniarz - Chicago IL

A61F 202

424425, 424424

Premature Rupture of the Membranes (PROM) is a serious complication of pregnancy. PROM is treated by creation of a seal or barrier at the site of the rupture or in or near the cervix, thereby controlling the loss of amniotic fluid and preventing bacterial access. Instruments and techniques for application of sealing and barrier-forming materials at appropriate sites are described, as well as appropriate selection of materials and formation techniques. The instruments and techniques facilitate application of any fluent material to physiology associated with pregnancy and rendering the fluent material non fluent so as to form a barrier of seal.

6468520, Oct 22, 2002

Dec 20, 1999

09/467359

Stephen C. Rowe - Wellesley MA
Jeffrey A. Hubbell - San Marino CA
Stephen J. Herman - Andover MA
Vae Sun - Palo Alto CA
Michael F. Lang - North Andover MA
George E. Selecman - Marblehead MA
Frederick F. Ahari - Newton MA

Focal, Inc. - Lexington MA

A61K 3174

424 7808, 424426, 604 20

An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to actinic light. The device, and methods that may be practiced in association with the device, enable a wide range of medical conditions to be treated including, for example, the application of a barrier to soft tissue to prevent post-surgical adhesions.

6176871, Jan 23, 2001

Oct 14, 1998

9/172537

Chandrashekhar P. Pathak - Waltham MA
Amarpreet S. Sawhney - Lexington MA
Jeffrey A. Hubbell - San Marino CA
Stephen J. Herman - Andover MA
Laurence A. Roth - Windham NH
Patrick K. Campbell - Georgetown MA
Kevin M. Berrigan - Woburn MA
Peter K. Jarrett - Southbury CT
Arthur J. Coury - Boston MA

Focal, Inc. - Lexington MA

A61F 206

623 1

A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.

7226442, Jun 5, 2007

Oct 10, 2001

09/975672

Stephen J. Herman - Andover MA, US
Michael J. Cima - Winchester MA, US
Robert S. Langer - Newton MA, US
Dennis Ausiello - Wellsley Hill MA, US

MicroCHIPS, Inc. - Bedford MA

A61K 9/22

6048901, 6048911, 604 93, 128899

Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate said release or exposure of the reservoir contents. In another embodiment, the system comprises (1) a microchip device comprising a substrate a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a telemetry system for the wireless transfer of data between the microchip device and a remote controller.

7910151, Mar 22, 2011

Oct 27, 2005

11/260526

Scott A. Uhland - Roslindale MA, US
Benjamin F. Polito - Cambridge MA, US
John M. Maloney - Cambridge MA, US
Stephen J. Herman - Andover MA, US
Barry Y. Yomtov - Marblehead MA, US

MicroCHIPS, Inc. - Bedford MA

A61L 33/00

427 21, 6048901, 119650, 119654, 427 58

Devices and methods for the controlled release or exposure of reservoir contents, and methods of manufacture thereof, are provided. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. The controlled release system may be incorporated into an implantable drug delivery or biosensing device.

4850351, Jul 25, 1989

Nov 25, 1986

6/934629

Stephen J. Herman - Andover MA
Laurence A. Roth - Hudson NH
Edward L. Sinofsky - Reading MA
Douglas W. Dickinson - Merrimack NH

C. R. Bard, Inc. - Murray Hill NJ

A61B 1736

1283031

A catheter having optical fibers for delivering laser energy to a blood vessel to remove obstructions in the blood vessel is adapted to be guided controllably and selectively by a guide wire to the site to be treated. The catheter includes a central lumen which is open at the distal end of the catheter and which receives the guide wire so that the catheter may be advanced over the guide wire. A relatively few number of optical fibers are contained within and extend longitudinally of the catheter wall. The distal tip of the catheter is provided with a cylindrical optically transparent end cap and means are provided to securely mount the distal ends of the optical fibers with respect to the end cap so that the light emitted from the ends of the fibers passes through the cylindrical wall of the end cap and is emitted at the distal emissions face of the end cap. The catheter embodies a special construction of an inner catheter core and a surrounding sheath which provides for a high degree of flexibility to enable the catheter to be passed through tortuous passages in a patient's vasculature. The inner core is formed from a plurality of articulated segments and is surrounded by a thin flexible sheath.

5849035, Dec 15, 1998

Oct 30, 1995

8/448572

Chandrashekhar P. Pathak - Waltham MA
Amarpreet S. Sawhney - Lexington MA
Jeffrey A. Hubbell - San Marino CA
Stephen J. Herman - Andover MA
Laurence A. Roth - Windham NH
Patrick K. Campbell - Georgetown MA
Kevin M. Berrigan - Woburn MA
Peter K. Jarrett - Southbury CT
Arthur J. Coury - Boston MA

Focal, Inc. - Lexington MA

A61F 206

623 1

A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.

7455667, Nov 25, 2008

Oct 26, 2005

11/259301

Scott A. Uhland - Roslindale MA, US
Benjamin F. Polito - Cambridge MA, US
John M. Maloney - Cambridge MA, US
Stephen J. Herman - Andover MA, US
Barry Y. Yomtov - Marblehead MA, US

MicroCHIPS, Inc. - Bedford MA

A61K 9/22

6048901, 604500

Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.

5779673, Jul 14, 1998

Jun 26, 1995

8/494333

Laurence A. Roth - Windham NH
Stephen J. Herman - Andover MA
Farhad Khosravi - San Mateo CA
David Melanson - Hudson NH
Michael Dumont - Stratham NH
Patrick K. Campbell - Georgetown MA
John C. Spiridigliozzi - Dedham MA

Focal, Inc. - Lexington MA

A61M 2500

604101

Devices for providing polymeric layers on the interior surface of body lumens and spaces are disclosed. The devices can include proximal and distal occlusion elements to define the treatment space and an optical emitter to provide light for a photopolymerization procedure. The devices may include a molding member for providing a thick polymeric gel. Alternatively, devices without a molding member may be used to carry out an interfacial polymerization procedure.

6004547, Dec 21, 1999

Sep 29, 1997

8/944035

Stephen C. Rowe - Wellesley MA
Jeffrey A. Hubbell - San Marino CA
Stephen J. Herman - Andover MA
Vae Sun - Palo Alto CA
Michael F. Lang - North Andover MA
George E. Selecman - Salem MA
Frederick F. Ahari - Newton MA

Focal, Inc. - Lexington MA

A61K 3174, A61K 202, A61N 130

424 7804

An apparatus is provided for applying to a surface of mammalian tissue including soft, living tissue an initially fluent material and then activating the material by exposure to an energy source. The material may be a liquid capable of polymerization to a non-fluent state by exposure to actinic light. The device, and methods that may be practised in association with the device, enable a wide range of medical conditions to be treated including, for example, the application of a barrier to soft tissue to prevent post-surgical adhesions.