STEPHEN J RUSSELL, M.D.
Osteopathic Medicine at 1 St, Rochester, MN
License number
Minnesota 45479
Category
Osteopathic Medicine
Type
Hematology
Address
Address
200 1St St SW, Rochester, MN 55905
Phone
(507) 284-2511
Professional information
Methods And Compositions For Identifying A Protease
US Patent:
6506557, Jan 14, 2003
Filed:
Feb 23, 2001
Appl. No.:
09/792416
Inventors:
Mark P. Chadwick - Cambridge, GB
Stephen J. Russell - Rochester MN
Stephen J. Russell - Rochester MN
Assignee:
BioFocus Discovery Limited - Cambridge
International Classification:
C12Q 170
US Classification:
435 5, 435 71, 435 39, 435325, 435334, 435339
Abstract:
Methods are disclosed whereby protease activity is directly linked to replication of viral display packages containing protease-encoding polynucleotides in target cells. The methods can be used, inter alia, to identify proteases, including previously undiscovered proteases or variants of known proteases which may have altered substrate specificity.
Dr. Stephen J Russell, Rochester MN - MD (Doctor of Medicine)
Specialties:
Hematology
Address:
Mayo Clinic
200 1St St SW, Rochester 55905
(507) 284-2511 (Phone)
200 1St St SW, Rochester 55905
(507) 284-2511 (Phone)
Languages:
English
Hospitals:
Mayo Clinic
200 1St St SW, Rochester 55905
Mayo Clinic Methodist Hospital
201 West Center St, Rochester 55902
200 1St St SW, Rochester 55905
Mayo Clinic Methodist Hospital
201 West Center St, Rochester 55902
Therapeutic Methods And Compositions Using Viruses Of The Recombinant Paramyxoviridae Family
US Patent:
2005021, Sep 29, 2005
Filed:
May 9, 2005
Appl. No.:
11/125940
Inventors:
Stephen Russell - Rochester MN, US
Roberto Cattaneo - Rochester MN, US
Kah-Whye Peng - Rochester MN, US
Urs Schneider - Rochester MN, US
Anthea Murphy - Rochester MN, US
Roberto Cattaneo - Rochester MN, US
Kah-Whye Peng - Rochester MN, US
Urs Schneider - Rochester MN, US
Anthea Murphy - Rochester MN, US
International Classification:
A61K049/00, A61K048/00
US Classification:
424009100, 424093200
Abstract:
The invention relates to compositions and methods for treating a patient having a tumor in order to reduce tumor size, comprising administering to the patient a replication-competent Paramyxoviridae virus comprising two or more of a) a nucleic acid sequence encoding a heterologous polypeptide, wherein upon administration the heterologous polypeptide is detectable in a biological fluid of the patient, and detection of the heterologous polypeptide is indicative of Paramyxoviridae virus growth in the patient and reduction in tumor size; b) a recombinant F protein, H protein, or M protein of Paramyxoviridae virus that increases fusogenicity of virus with cells; c) a nucleic acid sequence encoding a cytokine; and d) a Paramyxoviridae virus that is specific for cells of the tumor.
Expression Of Immonogenic Substances
US Patent:
2004024, Dec 2, 2004
Filed:
Jan 13, 2004
Appl. No.:
10/756818
Inventors:
Stephen Russell - Rochester MN, US
Luis Vallina - Madrid, ES
Robert Hawkins - Cheshire, GB
Luis Vallina - Madrid, ES
Robert Hawkins - Cheshire, GB
Assignee:
Mayo Foundation for Medical Education and Research, a Minnesota corporation
International Classification:
A61K048/00, A61K039/00
US Classification:
514/044000, 424/185100
Abstract:
Disclosed is a method of regulating the expression in a human or animal subject of a nucleic acid sequence encoding a polypeptide which is immunogenic in the subject; the method comprising introducing into a mammal a cell comprising the nucleic acid sequence encoding the immunogenic polypeptide, said sequence being operably linked to a drug-regulatable promoter; and altering the concentration of regulatory drug to which the cell is exposed.
Method For Limiting The Growth Of Cancer Cells Using An Attenuated Measles Virus
US Patent:
7854928, Dec 21, 2010
Filed:
Jan 15, 2010
Appl. No.:
12/688623
Inventors:
Stephen J. Russell - Rochester MN, US
Adele Kay Fielding - Cambridge, GB
Kah-Whye Peng - Rochester MN, US
Deanna Grote - Rochester MN, US
Adele Kay Fielding - Cambridge, GB
Kah-Whye Peng - Rochester MN, US
Deanna Grote - Rochester MN, US
Assignee:
Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:
A01N 63/00, C12N 7/00, C12N 7/04, C12N 7/02
US Classification:
424 936, 424 931, 4352351, 435236, 435239
Abstract:
A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 10pfus to about 10pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.
Method For Limiting The Growth Of Cancer Cells Using An Attenuated Measles Virus
US Patent:
7393527, Jul 1, 2008
Filed:
Sep 18, 2006
Appl. No.:
11/532879
Inventors:
Stephen James Russell - Rochester MN, US
Adele Fielding - Rochester MN, US
Kah-Whye Peng - Rochester MN, US
Deanna Grote - Rochester MN, US
Adele Fielding - Rochester MN, US
Kah-Whye Peng - Rochester MN, US
Deanna Grote - Rochester MN, US
Assignee:
Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:
A01N 63/00, C12N 7/00, C12N 7/02, C12N 7/04, C12N 15/00
US Classification:
424 936, 424 931, 4352351, 435236, 435239
Abstract:
A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 10pfus to about 10pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.
Avian Leukosis Viruses And Polypeptide Display
US Patent:
7625742, Dec 1, 2009
Filed:
Oct 8, 2008
Appl. No.:
12/247628
Inventors:
Mark J. Federspiel - Rochester MN, US
Stephen J. Russell - Rochester MN, US
Pranay D. Khare - Rochester MN, US
Stephen J. Russell - Rochester MN, US
Pranay D. Khare - Rochester MN, US
Assignee:
Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:
C12N 7/01, C12N 15/86, C07K 19/00, C07K 14/15
US Classification:
4352351, 4353201, 530350
Abstract:
The invention provides methods and materials involved in displaying polypeptide sequences using viruses such as avian leukosis viruses. Specifically, the invention provides nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses as well as methods for making nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses. The invention also provides methods for obtaining displayed polypeptide sequences that interact with biological molecules and/or cells as well as methods for identifying biological molecules that interact with displayed polypeptides.
Method For Limiting The Growth Of Cancer Cells Using An Attenuated Measles Virus
US Patent:
7670598, Mar 2, 2010
Filed:
Jun 9, 2008
Appl. No.:
12/135721
Inventors:
Stephen J. Russell - Rochester MN, US
Adele Kay Fielding - Cambridge, GB
Kah-Whye Peng - Rochester MN, US
Deanna Grote - Rochester MN, US
Adele Kay Fielding - Cambridge, GB
Kah-Whye Peng - Rochester MN, US
Deanna Grote - Rochester MN, US
Assignee:
Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:
A01N 63/00, C12N 7/00, C12N 7/04, C12N 7/02
US Classification:
424 936, 424 931, 4352351, 435236, 435239
Abstract:
A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 10pfus to about 10pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.
Vesicular Stomatitis Viruses
US Patent:
2013025, Sep 26, 2013
Filed:
Sep 1, 2011
Appl. No.:
13/820453
Inventors:
Stephen James Russell - Rochester MN, US
Shruthi Naik - Rochester MN, US
Shruthi Naik - Rochester MN, US
Assignee:
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN
International Classification:
C12N 7/00, C07K 14/705, C07K 14/565
US Classification:
424 932, 4352351
Abstract:
This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding VSV polypeptides, methods for making vesicular stomatitis viruses, and methods for using vesicular stomatitis viruses to treat cancer are provided.
Avian Leukosis Viruses And Polypeptide Display
US Patent:
7449322, Nov 11, 2008
Filed:
Oct 12, 2006
Appl. No.:
11/548743
Inventors:
Mark J. Federspiel - Rochester MN, US
Stephen J. Russell - Rochester MN, US
Pranay D. Khare - Rochester MN, US
Stephen J. Russell - Rochester MN, US
Pranay D. Khare - Rochester MN, US
Assignee:
Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:
C12N 7/01, C12N 15/86, C07K 19/00, C07K 14/15
US Classification:
4352351, 4353201, 530350
Abstract:
The invention provides methods and materials involved in displaying polypeptide sequences using viruses such as avian leukosis viruses. Specifically, the invention provides nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses as well as methods for making nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses. The invention also provides methods for obtaining displayed polypeptide sequences that interact with biological molecules and/or cells as well as methods for identifying biological molecules that interact with displayed polypeptides.