Inventors:
Stephen I-Hong Hsu - Gainesville FL, US
Assignee:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. - Gainesville FL
International Classification:
A61K 47/34, A61K 47/10, A61K 47/22
US Classification:
424 852, 514788, 424649, 514 27, 514 34, 514 211, 514 209, 514249, 514 59, 514635, 514369, 514592, 514342, 51421711, 51425506, 514423, 514412, 514331, 514563, 514 54, 4241841
Abstract:
The present invention provides thermo-sensitive, mucoadhesive biopolymer formulations that enhance the penetration of therapeutics across the skin or mucosal surfaces. In a preferred embodiment, the biopolymer formulation comprises co-polymer of poloxamer 188 and propylene glycol, laurocapram and, optionally, one or more therapeutic agents. Also provided are uses of the biopolymer formulations for topical therapy of cancer including cervical cancer.