DR. STEPHEN F. BADYLAK, DVM, MD, PHD
Medical Practice at Kingswood Rd, Lafayette, IN
License number
Indiana 01034583A
Category
Medical Practice
Type
Research Study
Address
Address
1150 Kingswood Rd S, Lafayette, IN 47906
Phone
(412) 624-5253
Professional information
Biomaterial Derived From Vertebrate Liver Tissue
US Patent:
6793939, Sep 21, 2004
Filed:
Apr 29, 2002
Appl. No.:
10/134416
Inventors:
Stephen F. Badylak - West Lafayette IN
Assignee:
Purdue Research Foundation - West Lafayette IN
International Classification:
A61K 35407
US Classification:
424553
Abstract:
A tissue graft composition comprising liver basement membrane is described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.
Tissue Graft Composition
US Patent:
4956178, Sep 11, 1990
Filed:
Nov 6, 1989
Appl. No.:
7/432591
Inventors:
Stephen F. Badylak - West Lafayette IN
Leslie A. Geddes - West Lafayette IN
Gary Lantz - Lafayette IN
Arthur C. Coffey - Indianapolis IN
Leslie A. Geddes - West Lafayette IN
Gary Lantz - Lafayette IN
Arthur C. Coffey - Indianapolis IN
Assignee:
Purdue Research Foundation - West Lafayette IN
International Classification:
A61K 3538, A61F 206
US Classification:
424551
Abstract:
This invention relates to a method for preparation of a tissue graft composition from a segment of small intestine. A tissue graft composition is described which comprises the tunica submucosa of a segment of small intestine of a warm-blooded vertebrate wherein the tunica submucosa is deliminated from the tunica muscularis and at least the luminal portion of the tunica mucosa. The tissue graft composition has been shown to have excellent mechanical characteristics, as well as non-allergenicity and non-thrombogenicity in applications as vascular autografts, vascular allografts, and vascular heterografts.
Scaffold For Cell Growth And Differentiation
US Patent:
2009007, Mar 19, 2009
Filed:
Aug 14, 2008
Appl. No.:
12/191786
Inventors:
Stephen F. Badylak - West Lafayette IN, US
International Classification:
A61K 35/12, C12N 5/06, A01N 1/02
US Classification:
424 937, 435395, 435401, 435 11
Abstract:
The present invention provides a devitalized mammalian parenchymatous tissue composition which includes an interstitial structure which can serve as a scaffold for tissue repair or regeneration. The devitalized mammalian parenchymatous tissue composition can further include the basement membrane of the tissue.
Multilayered Submucosal Graft Constructs And Method For Making The Same
US Patent:
5955110, Sep 21, 1999
Filed:
Nov 12, 1996
Appl. No.:
8/776490
Inventors:
Umesh H. Patel - West Lafayette IN
Michael C. Hiles - Indianapolis IN
Bryan A. Whitson - West Lafayette IN
Boyle Cheng - Greeley CO
Stephen F. Badylak - West Lafayette IN
Klod Kokini - Lafayette IN
Michael C. Hiles - Indianapolis IN
Bryan A. Whitson - West Lafayette IN
Boyle Cheng - Greeley CO
Stephen F. Badylak - West Lafayette IN
Klod Kokini - Lafayette IN
Assignee:
Purdue Research Foundation, Inc. - West Lafayette IN
Methodist Hospital of Indiana, Inc. - Indianapolis IN
Methodist Hospital of Indiana, Inc. - Indianapolis IN
International Classification:
A61K 3538
US Classification:
424551
Abstract:
Multi-laminar tissue graft constructs, pseudoisotropic graft constructs and a method of preparing such constructs are described. Multi-laminar tissue graft constructs are prepared by fusing partially overlapped strips of submucosa tissue into a unitary graft construct by compressing the tissue under dehydrating conditions. Pseudoisotropic tissue graft constructs are prepared by overlapping a first strip of submucosa tissue with at least two strips of submucosa tissue orientated so that the longitudinal axis of each strip formts an angle of about 180. degree. /N with the longitudinal axes of at least two other strips of submucosal tissue.
Tissue Graft Composition
US Patent:
4902508, Feb 20, 1990
Filed:
Jul 11, 1988
Appl. No.:
7/217299
Inventors:
Stephen F. Badylak - West Lafayette IN
Leslie A. Geddes - West Lafayette IN
Gary Lantz - Lafayette IN
Arthur C. Coffey - Indianapolis IN
Leslie A. Geddes - West Lafayette IN
Gary Lantz - Lafayette IN
Arthur C. Coffey - Indianapolis IN
Assignee:
Purdue Research Foundation - West Lafayette IN
International Classification:
A65R 3538
US Classification:
424 95
Abstract:
This invention relates to a method for preparation of a tissue graft composition from a segment of small intestine. A tissue graft composition is described which comprises the tunica submucosa of a segment of small intestine of a warm-blooded vertebrate wherein the tunica submucosa is delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa. The tissue graft composition has been shown to have excellent mechanical characteristics, as well as non-allergenicity and non-thrombogenicity in applications as vascular autografts, vascular allografts, and vascular heterografts.
Galactosidase Modified Submucosal Tissue
US Patent:
6331319, Dec 18, 2001
Filed:
Feb 2, 2000
Appl. No.:
9/463937
Inventors:
Stephen F. Badylak - West Lafayette IN
Rae Denese Record - Lafayette IN
Timothy B. McPherson - Columbia IL
Rae Denese Record - Lafayette IN
Timothy B. McPherson - Columbia IL
Assignee:
Purdue Research Foundation - West Lafayette IN
International Classification:
A61K 3538
US Classification:
424551
Abstract:
A tissue graft composition comprising submucosal tissue that has been enzymatically treated with galactosidase is described. The galactosidase modified submucosal tissue can be implanted to replace or support damaged or diseased tissues or utilized to form a cell culture growth substrate.
Biomaterial Derived From Vertebrate Liver Tissue
US Patent:
7919121, Apr 5, 2011
Filed:
Jan 9, 2003
Appl. No.:
10/500511
Inventors:
Stephen Francis Badylak - West Lafayette IN, US
Eric James Rodenberg - West Lafayette IN, US
Eric James Rodenberg - West Lafayette IN, US
Assignee:
Purdue Research Foundation - West Lafayette IN
International Classification:
A61K 35/12, A61K 35/407, A61K 35/32, A61K 35/36
US Classification:
424574, 424520, 424553, 424572
Abstract:
A tissue graft composition comprising liver basement membrane and a method of preparation of this tissue graft composition are described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues.
Fluidized Intestinal Submucosa And Its Use As An Injectable Tissue Graft
US Patent:
5516533, May 14, 1996
Filed:
Nov 22, 1994
Appl. No.:
8/343204
Inventors:
Stephen F. Badylak - West Lafayette IN
Robert J. Demeter - Mooresville IN
Michael Hiles - Indianapolis IN
Sherry Voytik - West Lafayette IN
Peter M. Knapp - Carmel IN
Robert J. Demeter - Mooresville IN
Michael Hiles - Indianapolis IN
Sherry Voytik - West Lafayette IN
Peter M. Knapp - Carmel IN
Assignee:
Purdue Research Foundation - West Lafayette IN
Methodist Hospital of Indiana, Inc. - Indianapolis IN
Methodist Hospital of Indiana, Inc. - Indianapolis IN
International Classification:
A61K 3538
US Classification:
424551
Abstract:
A fluidized, injectable tissue graft composition is described. The composition comprises comminuted intestinal submucosa or protease-digested intestinal submucosa. Methods for the preparation and use of injectable tissue graft compositions are described. In preferred embodiments the tissue graft material is prepared from the intestinal submucosa comprising the tunica submucosa, the muscularis mucosa and the stratum compactum of a segment of intestinal tissue of a warm-blooded vertebrate. Effective amounts of the fluidized graft compositions can be injected to promote repair tissue defects by inducing formation of endogenous tissues.
Method Of Repairing Perforated Submucosal Tissue Graft Constructs
US Patent:
5968096, Oct 19, 1999
Filed:
Aug 6, 1997
Appl. No.:
8/908151
Inventors:
Bryan Whitson - West Lafayette IN
Boyle Cheng - Greeley CO
Stephen F. Badylak - West Lafayette IN
Boyle Cheng - Greeley CO
Stephen F. Badylak - West Lafayette IN
Assignee:
Purdue Research Foundation - West Lafayette IN
Clarian Health Partners - Indianapolis IN
Clarian Health Partners - Indianapolis IN
International Classification:
A61F 202, A61F 210, A61K 3538
US Classification:
623 15
Abstract:
A perforated unitary multi-laminar tissue graft construct and method for preparing such construct is described. The method comprises overlapping strips of submucosa tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.
Tissue Regenerative Composition
US Patent:
2004004, Mar 4, 2004
Filed:
Aug 27, 2002
Appl. No.:
10/228927
Inventors:
Stephen Badylak - West Lafayette IN, US
Robert Tullius - Brookston IN, US
Nathan Huber - Indianapolis IN, US
Kristina Lindberg - West Lafayette IN, US
Alan Spievack - Cambridge MA, US
Robert Tullius - Brookston IN, US
Nathan Huber - Indianapolis IN, US
Kristina Lindberg - West Lafayette IN, US
Alan Spievack - Cambridge MA, US
International Classification:
A61K045/00, A61K009/22
US Classification:
424/093700, 424/468000
Abstract:
A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.