Inventors:
Stephen C. Pflugfelder - Miami FL
Balakrishna L. Lokeshwar - Miami FL
Marie Selzer - Fort Lauderdale FL
Assignee:
The University of Miami - Miami FL
International Classification:
A01N 3734
Abstract:
A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the method concerns treatment of a patient with topical tetracycline, a derivative or analogue of tetracycline, or a chemically modified tetracycline (CMT). Oral administration of a CMT is also disclosed as part of the method for treating meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion.