STEPHEN C BLACKLOW, M.D.
Medical Practice at Avenue Louis Pasteur, Boston, MA
License number
Massachusetts 81307
Category
Medical Practice
Type
Clinical Pathology/Laboratory Medicine
Address
Address
2
77 Avenue Louis Pasteur, Boston, MA 02115
16 Ash St, Cambridge, MA 02138
16 Ash St, Cambridge, MA 02138
Phone
(617) 525-4415
Personal information
See more information about STEPHEN C BLACKLOW at radaris.comName
Address
Phone
16 Ash St, Cambridge, MA 02138
13 Everett House, Cambridge, MA 02138
D, Cambridge, MA 02138
116 Tower Rd, Lincoln, MA 01773
16 Ash St, Cambridge, MA 02138
Professional information
Stephen Charles Blacklow, Boston MA
Specialties:
Pathologist
Address:
77 Avenue Louis Pasteur, Boston, MA 02115
Education:
Harvard Medical School - Doctor of Medicine
Harvard University - Doctor of Philosophy
Brigham & Women's Hospital - Residency - Pathology
Harvard University - Doctor of Philosophy
Brigham & Women's Hospital - Residency - Pathology
Board certifications:
American Board of Pathology Certification in Clinical Pathology (Pathology)
Dr. Stephen C Blacklow, Boston MA - MD (Doctor of Medicine)
Specialties:
Clinical Pathology
Address:
77 Avenue Louis Pasteur, Boston 02115
(617) 525-4415 (Phone)
BRIGHAM & WOMENS HOSPITAL
77 Avenue Louis Pasteur, Boston 02115
(617) 525-5330 (Phone), (617) 525-5330 (Fax)
(617) 525-4415 (Phone)
BRIGHAM & WOMENS HOSPITAL
77 Avenue Louis Pasteur, Boston 02115
(617) 525-5330 (Phone), (617) 525-5330 (Fax)
Certifications:
Clinical Pathology, 1996
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Harvard Medical School
Graduated: 1991
Brigham and Womens Hospital
Harvard Medical School
Graduated: 1991
Brigham and Womens Hospital
Generation And Characterization Of Anti-Notch Antibodies For Therapeutic And Diagnostic Use
US Patent:
2011028, Nov 24, 2011
Filed:
Nov 16, 2009
Appl. No.:
13/130441
Inventors:
Ningyan Zhang - Ambler PA, US
Fubao Wang - Dresher PA, US
Andrew Bett - Lansdale PA, US
Anna Demartis - Rome, IT
Maurizio Nuzzo - Rome, IT
Paolo Monaci - Rome, IT
Stephen Blacklow - Cambridge MA, US
Jon Aster - Lexington MA, US
Fubao Wang - Dresher PA, US
Andrew Bett - Lansdale PA, US
Anna Demartis - Rome, IT
Maurizio Nuzzo - Rome, IT
Paolo Monaci - Rome, IT
Stephen Blacklow - Cambridge MA, US
Jon Aster - Lexington MA, US
International Classification:
A61K 39/395, C12N 1/20, A61P 35/00, A61K 49/00, A61K 51/10, C12N 9/96, C07K 16/28, G01N 33/53
US Classification:
424 149, 5303891, 5303873, 4352521, 4352528, 4352525, 4352533, 435 792, 435 723, 424 91, 4241721, 4241781, 5303917, 5303913, 435188
Abstract:
The present invention relates to mammalian antibodies, preferably fully human monoclonal antibodies and antigen-binding portions thereof that specifically bind to a cell surface receptor, wherein the receptor protein is a Notch1 receptor protein. Some of the disclosed antibodies bind Notch1 to the exclusion of other members of the Notch receptor family, while other antibodies bind Notch 1 and Notch3. Nucleic acid molecules encoding the Notch antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of Notch1 or Notch3 including aberrant activation of each of these receptors.
Rap Variants For Drug Delivery And Methods Of Use Thereof
US Patent:
8236753, Aug 7, 2012
Filed:
Dec 10, 2008
Appl. No.:
12/747354
Inventors:
Stephen Blacklow - Cambridge MA, US
Carl Fisher - Watertown MA, US
Kristine Estrada - Chino Hills CA, US
Carl Fisher - Watertown MA, US
Kristine Estrada - Chino Hills CA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 38/00, A61K 47/00, C07K 1/00, C07K 14/00, C07K 16/00, C07K 17/00, C08H 1/00
US Classification:
514 12, 530350, 530402
Abstract:
The present invention relates to stabilized RAP variants and methods of use thereof. Conjugates of stabilized RAP variants to therapeutic compounds and stabilized RAP fusion proteins comprising therapeutic polypeptides are also presented.
Notch Mutations Leading To Increased Receptor Signaling
US Patent:
2010008, Apr 8, 2010
Filed:
May 22, 2009
Appl. No.:
12/453833
Inventors:
Jon C. Aster - Lexington MA, US
Stephen C. Blacklow - Cambridge MA, US
A. Thomas Look - North Reading MA, US
Adolfo A. Ferrando - New York NY, US
Andrew P. Weng - Vancouver, CA
Stephen C. Blacklow - Cambridge MA, US
A. Thomas Look - North Reading MA, US
Adolfo A. Ferrando - New York NY, US
Andrew P. Weng - Vancouver, CA
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
Dana-Farber Cancer Institute, Inc. - Boston MA
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
A61K 38/02, A61K 31/352, A61K 31/336, A61K 31/12, A61P 35/02
US Classification:
514 2, 514457, 514475, 514675
Abstract:
The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.
Functional Negative Regulatory Domain Sequences From Human Notch1 And 2 And Isolated Lnr Domains From Human Notch1
US Patent:
2008024, Oct 2, 2008
Filed:
May 15, 2007
Appl. No.:
11/803705
Inventors:
Stephen Blacklow - Cambridge MA, US
Wendy Ryan Gordon - Jamaica Plain MA, US
Cheryll Sanchez-Irizarry - San Mateo CA, US
Jon C. Aster - Lexington MA, US
Wendy Ryan Gordon - Jamaica Plain MA, US
Cheryll Sanchez-Irizarry - San Mateo CA, US
Jon C. Aster - Lexington MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 39/395, C07K 14/00, A61K 31/70, C12P 21/04, C07H 21/04, G01N 33/53, C12N 5/00, C07K 16/00
US Classification:
4241391, 530300, 514 44, 5303879, 435375, 435 696, 435 71, 536 235
Abstract:
The present invention relates to a LNR-HD domain of the Notch receptor and methods of use. The method for expression and structural determination of the LNR-HD domain is described.
Notch Mutations Leading To Increased Receptor Signaling
US Patent:
2007007, Apr 5, 2007
Filed:
Aug 2, 2005
Appl. No.:
11/194913
Inventors:
Jon Aster - Lexington MA, US
Stephen Blacklow - Cambridge MA, US
A. Look - North Reading MA, US
Adolfo Ferrando - New York NY, US
Andrew Weng - Vancouver, CA
Stephen Blacklow - Cambridge MA, US
A. Look - North Reading MA, US
Adolfo Ferrando - New York NY, US
Andrew Weng - Vancouver, CA
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
Dana-Farber Cancer Institute, Inc. - Boston MA
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
G01N 33/574, C07H 21/04, C12P 21/06, A61K 39/395, C07K 14/705
US Classification:
424144100, 530350000, 435069100, 435320100, 435325000, 536023500, 530388220, 435007230
Abstract:
The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increased receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.