STEPHEN BERNARD RUDDY
Pharmacy in Collegeville, PA
License number
Pennsylvania RP034839L
Category
Pharmacy
Type
Pharmacist
Address
Address
Collegeville, PA 19426
Professional information
Compositions Of Iodophenyl Esters And Iodophenyl Sulfonates And Pharmaceutically Acceptable Clays For Visualization Of The Gastrointestinal Tract
US Patent:
5472682, Dec 5, 1995
Filed:
May 26, 1994
Appl. No.:
8/249424
Inventors:
Stephen B. Ruddy - Schwenksville PA
Mary E. Roberts - Downingtown PA
Gregory L. McIntire - West Chester PA
Eugene R. Cooper - Berwyn PA
Kimberly G. Estep - Pottstown PA
Mary E. Roberts - Downingtown PA
Gregory L. McIntire - West Chester PA
Eugene R. Cooper - Berwyn PA
Kimberly G. Estep - Pottstown PA
Assignee:
Sterling Winthrop Inc. - New York NY
International Classification:
A61K 4904, A61K 3122
US Classification:
424 945
Abstract:
Disclosed are x-ray contrast compositions of the formula ##STR1## wherein X is ##STR2## or --SO. sub. 2 --; Z is H, halo, methyl, ethyl, n-propyl, C. sub. 4 -C. sub. 20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;
R is C. sub. 1 -C. sub. 25 alkyl, cycloalkyl or aryl each of which may be optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl; lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy;
n is 1-5;
y is 0-4; and
w is 1-4;
in combination with a pharmaceutically acceptable clay; and method for their use in diagnostic radiology of the gastrointestinal tract.
Nanocrystalline Formulations Of Human Immunodeficiency Virus (Hiv) Protease Inhibitors Using Cellulosic Surface Stabilizers
US Patent:
6045829, Apr 4, 2000
Filed:
Jul 9, 1997
Appl. No.:
8/890602
Inventors:
Gary G. Liversidge - West Chester PA
David A. Engers - Collegeville PA
Mary E. Roberts - Downingtown PA
Stephen B. Ruddy - Schwenksville PA
Sui-Ming Wong - Collegeville PA
Shuqian Xu - Phoenixville PA
David A. Engers - Collegeville PA
Mary E. Roberts - Downingtown PA
Stephen B. Ruddy - Schwenksville PA
Sui-Ming Wong - Collegeville PA
Shuqian Xu - Phoenixville PA
Assignee:
Elan Pharma International Limited - Shannon
International Classification:
A61K 914
US Classification:
424489
Abstract:
The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increase rate of absorption in vivo, a decreased fed/fasted ratio variability, and a decreased variability in absorption. The present invention is also directed to methods of making the novel formulations. In particular, nanoparticulate formulations of HIV type 1 (HIV-1) and type 2 (HIV-2) protease inhibitors are described.
X-Ray Contrast Compositions Containing Iodoaniline Derivatives And Pharmaceutically Acceptable Clays
US Patent:
5424056, Jun 13, 1995
Filed:
Apr 29, 1994
Appl. No.:
8/236287
Inventors:
Stephen B. Ruddy - Schwenksville PA
Gregory L. McIntire - West Chester PA
Mary E. Roberts - Downingtown PA
Thomas J. Caulifield - Audubon PA
Eugene R. Cooper - Berwyn PA
Gregory L. McIntire - West Chester PA
Mary E. Roberts - Downingtown PA
Thomas J. Caulifield - Audubon PA
Eugene R. Cooper - Berwyn PA
Assignee:
Sterling Wintrhop Inc. - New York NY
International Classification:
A61K 4904, G01N 2100
US Classification:
424 945
Abstract:
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an iodoaniline derivative as the x-ray producing agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
Formulations For Therapeutic Agents Absorbed Through Mucous Membranes
US Patent:
2003005, Mar 20, 2003
Filed:
Jun 21, 2002
Appl. No.:
10/175851
Inventors:
Gary Liversidge - West Chester PA, US
W. Eickhoff - Lansdale PA, US
Kathleen Illig - Phoenixville PA, US
Pramod Sarpotdar - Malvern PA, US
Stephen Ruddy - Schwenksville PA, US
W. Eickhoff - Lansdale PA, US
Kathleen Illig - Phoenixville PA, US
Pramod Sarpotdar - Malvern PA, US
Stephen Ruddy - Schwenksville PA, US
Assignee:
Elan Pharma International Limited
International Classification:
A61K009/16, A61K009/50
US Classification:
424/497000
Abstract:
Particulate crystalline therapeutic substances are formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the mucosal membranes to provide extended therapeutic effect.
Rapidly Disintegrating Solid Oral Dosage Form
US Patent:
2009013, May 21, 2009
Filed:
Oct 31, 2007
Appl. No.:
11/979240
Inventors:
Rajeev A. Jain - Norristown PA, US
Stephen B. Ruddy - Schwenksville PA, US
Kenneth lain Cumming - Phibsoboro, IE
Maurice Joseph Anthony Clancy - Booterstown, IE
Janet Elizabeth Codd - County Westmeath, IE
Stephen B. Ruddy - Schwenksville PA, US
Kenneth lain Cumming - Phibsoboro, IE
Maurice Joseph Anthony Clancy - Booterstown, IE
Janet Elizabeth Codd - County Westmeath, IE
International Classification:
A61K 9/10
US Classification:
424485, 424484, 424486, 424488, 977906
Abstract:
Disclosed is a rapidly disintegrating solid oral dosage form of a poorly soluble active ingredient and at least one pharmaceutically acceptable water-soluble or water dispersible excipient, wherein the poorly soluble active ingredient particles have an average diameter, prior to inclusion in the dosage form, or less than about 2000 nm. The dosage form of the invention has the advantage of combining rapid presentation and rapid dissolution of the active ingredient in the oral cavity.
X-Ray Contrast Compositions Containing Iodophenoxyalkanes And Pharmaceutically Acceptable Clays
US Patent:
5476646, Dec 19, 1995
Filed:
Apr 21, 1994
Appl. No.:
8/230580
Inventors:
Stephen B. Ruddy - Schwenksville PA
Gregory L. McIntire - West Chester PA
Mary E. Roberts - Downingtown PA
John L. Toner - Downingtown PA
Gregory L. McIntire - West Chester PA
Mary E. Roberts - Downingtown PA
John L. Toner - Downingtown PA
Assignee:
Sterling Winthrop Inc. - New York NY
International Classification:
A61K 4904
US Classification:
424 945
Abstract:
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a nonionic x-ray producing agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
Injectable Nanoparticulate Olanzapine Formulations
US Patent:
2009015, Jun 18, 2009
Filed:
Dec 11, 2008
Appl. No.:
12/333233
Inventors:
Stephen B. Ruddy - Schwenksville PA, US
David Czekai - Spring City PA, US
Gary Liversidge - West Chester PA, US
Scott A. Jenkins - Downingtown PA, US
Elaine M. Liversidge - West Chester PA, US
David Czekai - Spring City PA, US
Gary Liversidge - West Chester PA, US
Scott A. Jenkins - Downingtown PA, US
Elaine M. Liversidge - West Chester PA, US
Assignee:
Elan Pharma International Limited - Co. Westmeath
International Classification:
A61K 9/14, A61K 31/551, A61P 25/00
US Classification:
424422, 514220, 977906, 977773
Abstract:
Described are injectable formulations of particulate olanzapine that produce a prolonged duration of action upon administration, and methods of making and using such formulations. The injectable formulations comprise particulate olanzapine.
Isolation Of Ultra Small Particles
US Patent:
5503723, Apr 2, 1996
Filed:
Feb 8, 1995
Appl. No.:
8/385531
Inventors:
Stephen B. Ruddy - Schwenksville PA
W. Mark Eickhoff - Dowingtown PA
W. Mark Eickhoff - Dowingtown PA
Assignee:
Eastman Kodak Company - Rochester NY
International Classification:
B01D 5702
US Classification:
204450
Abstract:
The present invention is a method and apparatus for further reducing the size of nanoparticles. Nanoparticles are defined as having an effective average particle size of less than about 400 nm. The present invention separates the nanoparticles further using electric fields.
Fenofibrate Dosage Forms
US Patent:
2008024, Oct 2, 2008
Filed:
Mar 28, 2008
Appl. No.:
12/058497
Inventors:
Tuula A. Ryde - Malvern PA, US
Evan E. Gustow - Villanova PA, US
Stephen B. Ruddy - Schwenksville PA, US
Rajeev Jain - Collegeville PA, US
Rakesh Patel - Bensalem PA, US
Michael John Wilkins - Terry Green, GB
Niels P. Ryde - Malvern PA, US
Evan E. Gustow - Villanova PA, US
Stephen B. Ruddy - Schwenksville PA, US
Rajeev Jain - Collegeville PA, US
Rakesh Patel - Bensalem PA, US
Michael John Wilkins - Terry Green, GB
Niels P. Ryde - Malvern PA, US
International Classification:
A61K 49/00, A61K 31/265, A61K 9/14
US Classification:
424 92, 514512, 424489
Abstract:
Disclosed are redispersible fibrate, such as fenofibrate, dosage forms. Also disclosed are in vitro methods for evaluating the in vivo effectiveness of fibrate, such as fenofibrate, dosage forms. The methods utilize media representative of in vivo human physiological conditions.
Nanoparticulate Fibrate Formulations
US Patent:
7276249, Oct 2, 2007
Filed:
May 23, 2003
Appl. No.:
10/444066
Inventors:
Tuula Ryde - Malvern PA, US
Evan E. Gustow - Villanova PA, US
Stephen B. Ruddy - Schwenksville PA, US
Rajeev Jain - Collegeville PA, US
Rakesh Patel - Bensalem PA, US
Michael John Wilkins - Co. Cork, IE
Evan E. Gustow - Villanova PA, US
Stephen B. Ruddy - Schwenksville PA, US
Rajeev Jain - Collegeville PA, US
Rakesh Patel - Bensalem PA, US
Michael John Wilkins - Co. Cork, IE
Assignee:
Elan Pharma International, Ltd. - Athlone, Co. Westmeath
Fournier Laboratories Ireland Ltd. - Cork
Fournier Laboratories Ireland Ltd. - Cork
International Classification:
A61K 9/48, A61K 9/20, A61K 9/14
US Classification:
424451, 424458, 424464, 424469, 424470, 424489, 424490
Abstract:
The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.