Inventors:
Paul F. Pollack - Bexley OH, US
Rebecca S. Hoffman - Wilmette IL, US
Cheryl L. Renz - Kildeer IL, US
Susan K. Paulson - Downers Grove IL, US
Zhuoying Peng - New York NY, US
William J. Sandborn - Rochester MN, US
Stephen B. Hanauer - Chicago IL, US
Paul Rutgeerts - Blanden, BE
International Classification:
A61K 39/395
Abstract:
The invention provides methods, uses and compositions for the treatment of Crohn's disease. The invention describes methods and uses for treating Crohn's disease, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to induce and maintain remission of Crohn's disease in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment of Crohn's disease in a subject.