Inventors:
Joseph R. Pisegna - Santa Monica CA, US
Stephen Wank - Potomac MD, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 38/00, A61K 49/00
US Classification:
514 2, 514 13, 514 17, 514199, 514256, 514338, 514361, 530300, 530326, 530330, 424 91
Abstract:
This invention pertains to the discovery administration of a CCK receptor agonist can increase urinary sodium excretion and/or free water excretion in a mammal. CCK receptor agonist can thereby be used in the treatment of conditions such high blood pressure, fluid retention associated with heart failure, fluid retention associated with acute or chronic kidney failure, fluid retention associated with cirrhosis, fluid retention associated with liver failure, calcium kidney stones, nephrogenic diabetes insipidus, and renal tubular acidosis.