Inventors:
Moses J. Folkman - Brookline MA
Stephanie Taylor - Boston MA
Robert S. Langer - Somerville MA
Assignee:
The Children's Medical Center Corporation - Boston MA
International Classification:
A61K 31725, A61K 3156
Abstract:
Angiogenesis in mammals is inhibited by administration of the active agents (1) heparin or a heparin fragment which is a hexasaccharide or larger or analogous compounds and (2) a steroid having 17. alpha. - and 21-hydroxy groups, 3- and 20-one groups, and in the 16-position hydrogen hydroxy or a methyl group, and non-toxic physiologically acceptable carboxylates, acetals, ketals and phosphates thereof.