Inventors:
Ronald G. Crystal - New York NY, US
Philip L. Leopold - Basking Ridge NJ, US
Stefan Worgall - New York NY, US
Julie L. Boyer - New York NY, US
Assignee:
CORNELL UNIVERSITY - Ithaca NY
International Classification:
A61K 39/235, A61K 31/7088, A61P 25/36, A61P 25/30, A61P 25/34, C12N 7/00, C12N 15/63
US Classification:
4241991, 4242331, 514 44 R, 4352351, 4353201
Abstract:
The invention provides an adenovirus-antigen conjugate comprising an adenovirus with a coat protein and an antigen of an addictive drug conjugated to the coat protein of the adenovirus. The invention also provides an adenoviral vector comprising a nucleic acid sequence which encodes an antibody directed against the addictive drug. The invention further provides a method of inducing an immune response against an addictive drug or reducing the effect of an addictive drug in a human by ad-ministering to the human the aforementioned adenovirus-antigen conjugate or antibody encoding adenoviral vector.