Inventors:
Rohit Kohli - Mason OH, US
Stavra A. Xanthakos - Cincinnati OH, US
Michael V. Miles - Mason OH, US
International Classification:
G01N 33/53, G01N 33/64
Abstract:
Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. Provided herein are biomarkers, methods, and animal models useful for the investigation and non-invasive detection of NASH, including a non-invasive biomarker that could be used to establish disease severity, follow progression, and evaluate response to treatment in clinical trials for this increasingly prevalent disease.