Inventors:
Raymond Tabibiazar - Menlo Park CA, US
Stanley G. Rockson - Stanford CA, US
International Classification:
A61K 31/192, A61P 7/10, C12Q 1/68, A61K 49/00, C40B 30/04, A61P 29/00, G01N 33/566
US Classification:
424 92, 514570, 435 721, 424 91, 506 9, 435 612, 435 611
Abstract:
The present invention identifies genes whose gene products are differentially expressed in lymphedema tissues, particularly cutaneous tissue involved in whole organ response to lymphedema. The invention provides methods for diagnosing or assessing an individual's susceptibility to lymphedema. Also provided are therapeutic methods for treating a patient or methods for prophylactically treating an individual susceptible to lymphedema. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have or at risk of developing lymphedema.