Inventors:
Stanley E. Shackney - Pittsburgh PA, US
Assignee:
Intelligent Oncotherapeutics, Inc. - Pittsburgh PA
International Classification:
A61K 38/17, C07D 403/14, A61K 31/506, C07F 9/6512, A61K 31/675, C07D 401/12, A61K 31/454, C07D 413/12, A61K 31/5377, C07D 487/04, A61K 31/55, C07D 403/04, A61K 31/497, C07K 14/47, C07C 43/23, A61K 31/085, C40B 60/12, A61P 35/00, G06F 19/00, C40B 30/04
US Classification:
514 192, 506 9, 544295, 51425219, 544244, 514 80, 546201, 514323, 544119, 5142345, 540578, 514215, 544405, 51425505, 530324, 568652, 514720, 530350, 506 39, 702 19
Abstract:
The disclosure relates to methods for identifying a tumor as an E2F-responsive gene over-expressing (ERGO) tumor, methods of determining the likelihood that an ERGO tumor patient will survive to a future date, methods of treating an ERGO tumor in a patient, and methods of selecting patients diagnosed as ERGO tumor prostate cancer patients for aggressive clinical treatment. The methods of the disclosure are applicable to ERGO tumors present in different human organs and tissues such as breast, lung, thyroid, ovary, and prostate.