Inventors:
LIANG XUE - Elk Grove CA, US
William K. Chan - Elk Grove CA, US
Stan W. Linnet - Redding CA, US
Timothy N. Linnet - Redding CA, US
International Classification:
A61K 31/519, A61P 25/30, A61P 9/00, C07D 471/12, A61K 31/522
Abstract:
The teachings provided herein generally relate to compositions comprising rutaecarpine derivatives that activates CYP1A2 through enzyme induction. The uses for such a derivative can include removing caffeine from a subject, improving sleep, treating insomnia, treating caffeine toxicity, treating caffeine addiction and withdrawal symptoms, and the like. Caffeine is just one example of a substrate that can be removed using the derivatives taught herein, and other examples, including theophylline, are provided herein.