Inventors:
JAMES D. RODGERS - Landenberg PA, US
Stacey Shepard - Wilmington DE, US
Wenyu Zhu - Media PA, US
Lixin Shao - Newark DE, US
Joseph Glenn - Mount Royal NJ, US
International Classification:
A61K 31/519, C07D 471/04, A61K 31/506, A61K 31/5377, A61P 37/00, A61P 35/00, A61P 29/00, A61P 19/08, A61P 37/06, A61P 17/00, A61P 25/00, A61P 19/02, A61P 3/10, A61P 19/04, A61P 1/00, A61P 21/04, A61P 1/16, A61P 9/10, A61P 5/12, A61P 17/06, A61P 35/02, A61P 19/10, C12N 9/99, C07D 487/04
US Classification:
51421021, 544280, 51425216, 51425211, 5142651, 544295, 51425218, 544117, 5142342, 435184
Abstract:
The present invention provides cyclobutyl substituted pyrrolopyrimidines and pyrrolopyridines of Formula I:wherein X, Y, Z, L, A, R, n and m are defined above, as well as their compositions and methods of use, that modulate the activity of Janus kinases (JAKs) and are useful in the treatment of diseases related to the activity of JAKs including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.