Inventors:
Matthew R. Redinbo - Durham NC, US
Sridhar Mani - Riverdale NY, US
Alfred Williams - Durham NC, US
John Scott - Durham NC, US
Li-An Yeh - Cary NC, US
Bret David Wallace - Chapel Hill NC, US
Kimberly Terry Lane - Christiansburg VA, US
Assignee:
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL - Chapel Hill NC
NORTH CAROLINA CENTRAL UNIVERSITY - Durham NC
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY - Bronx NY
International Classification:
A61K 31/4704, A61P 31/04, C07D 333/38, A61K 31/381, A61K 31/5377, A61K 31/496, C07D 487/04, C07D 405/10, C07D 495/14, C07D 215/227, C07D 495/04
US Classification:
5142328, 546157, 514312, 549 68, 514447, 544278, 51425216, 544281, 544377, 51425411, 544112
Abstract:
Compounds, compositions and methods are provided that comprise selective β-glucuronidase inhibitors for both aerobic and anaerobic bacteria, especially enteric bacteria normally associated with the gastrointestinal tract. The compounds, compositions and methods can be for inhibiting bacterial β-glucuronidases and for improving efficacy of camptothecin-derived antineoplastic agents or glucuronidase-substrate agents or compounds by attenuating the side effects caused by reactivation by bacterial β-glucuronidases of glucuronidated metabolites of camptothecin-derived antineoplastic agents or glucuronidase-substrate agents or compounds.