DR. SPENCER B KING, M.D.
Osteopathic Medicine in Atlanta, GA

5087244, Feb 11, 1992

Sep 27, 1990

7/590048

Harvey Wolinsky - New York NY
Spencer L. King - Atlanta GA
Michael D. Barbere - Dunstable MA

C. R. Bard, Inc. - Murray Hill NJ

A61M 2900

604 53

A method and catheter for use in practicing the method are provided by which a highly concentrated medication or chemotherapeutic agent can be applied locally under sufficient pressure to cause the medication or agent to penetrate into the localized tissue. The total volume of medication or agent is quite small, well below levels that might cause an adverse reaction in other parts of the body. The catheter includes a thin walled flexible balloon having a plurality of minute holes through which medication may flow at a low flow rate. The balloon is inflated with the medication under pressure and the flow rate of the order of a few ccs per minute is controlled by the minute holes in the balloon. In practicing the method of the invention, the balloon is selected such that its inflated diameter will correspond to or be slightly greater than the diameter of the lumen into which it is to be placed so that when the balloon is inflated, it will contact intimately the surface of the lumen. Inflation of the balloon with the medication will cause a thin film to spread between the balloon and the lumen, the film being maintained under a sufficient pressure to penetrate significantly the surrounding tissue with a high concentration of medication.

5709874, Jan 20, 1998

Jun 3, 1996

8/660203

Stephen R. Hanson - Stone Mountain GA
Neal A. Scott - Atlanta GA
Spencer B. King - Atlanta GA
Laurence A. Harker - Atlanta GA

Emory University - Atlanta GA

A61M 25088

424423

A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.

5523092, Jun 4, 1996

Jan 28, 1994

8/188248

Stephen R. Hanson - Stone Mountain GA
Neal A. Scott - Atlanta GA
Spencer B. King - Atlanta GA
Laurence A. Harker - Atlanta GA

Emory University - Atlanta GA

A61M 25088

424423

A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.

5383928, Jan 24, 1995

Aug 19, 1993

8/109149

Neal A. Scott - Atlanta GA
Stephen R. Hanson - Stone Mountain GA
Spencer B. King - Atlanta GA
Laurence A. Harker - Atlanta GA

Emory University - Atlanta GA

A61F 206, A61F 204

623 1

This invention provides a sheath for encompassing at least a portion of a stent to locally deliver a drug to an arterial wall or lumen into which the stent has been inserted, comprising a polymer and a drug incorporated within the polymer, the polymer sheath encompassing at least a portion of the stent and a thickness to allow controlled release of the drug. Also provided is a method of preventing thrombosis and promoting and inhibiting vascular growth in a subject comprising inserting a stent encompassed by the sheath of the invention into a vessel of the subject.

5985307, Nov 16, 1999

Dec 2, 1997

8/982537

Stephen R. Hanson - Stone Mountain GA
Neal A. Scott - Atlanta GA
Spencer B. King - Atlanta GA
Christos Markou - Dunwoody GA

Emory University - Atlanta GA

A61M 25088

424423

A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without substantially disrupting the fluid flow therethrough. For example, an indwelling endovascular support device is provided for delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.