Inventors:
Daniela Novick - Rehovot, IL
Charles Dinarello - Boulder CO
Menachem Rubinstein - Givat Shmuel, IL
Soo Hyun Kim - Denver CO
Assignee:
Yeda Research and Development Company Limited - Rehovot
International Classification:
A61K 3522
US Classification:
4241841, 4241851, 4241861, 4242041, 4242321, 424 851, 530350, 530351, 530395, 530820, 530826, 530827, 530834, 514 2, 514 8, 514 9
Abstract:
Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided.