SONJA S DICKEY
Medical Practice at Lk Magdalene Dr, Tampa, FL
License number
Florida 11863
Effective Date
Apr 2, 1998
Expiration Date
Jun 30, 1994
Category
Health Care
Type
Clinical Laboratory Personnel
Address
Address
13539 Lake Magdalene Dr, Tampa, FL 33613
Professional information
N-Thiolated -Lactam Antibiotics
US Patent:
6476015, Nov 5, 2002
Filed:
Jul 24, 2000
Appl. No.:
09/621646
Inventors:
Edward Turos - Temple Terrace FL
Edward T. Carpenter - Tampa FL
Timothy Long - Tampa FL
Daniel V. Lim - Tampa FL
Sonja S. Dickey - Tampa FL
Edward T. Carpenter - Tampa FL
Timothy Long - Tampa FL
Daniel V. Lim - Tampa FL
Sonja S. Dickey - Tampa FL
Assignee:
University of South Florida - Tampa FL
International Classification:
A61K 31397
US Classification:
51421015, 540355
Abstract:
Substituted monocyclic -lactam compounds that are N-1-thiolated monolactams, and which exhibit wide-ranging antibacterial activities, having a single 4-membered azetidinone ring in which: the N-1 nitrogen atom of the azetidinone ring is bonded to sulfur but is not sulfonated, of the formula: wherein R are independently hydrogen, alkyl, heteroalkyl, aryl, heteroaryl, alkenyl, or alkynyl; X is H, C, or O; and n=0-3. Chemical synthesis of these compounds by a [2+2]-imine-acid chloride cycloaddition, and methods for subsequent derivatization, are also disclosed. The compounds and compositions disclosed herein are useful as antibacterial and antibiotic agents.