Inventors:
George J. Brewer - Ann Arbor MI
Sofia D. Merajver - Ann Arbor MI
Dimitri Coucouvanis - Ann Arbor MI
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 3334
US Classification:
424641, 424646, 514 53, 514502
Abstract:
Provided are agents that can bind to copper, and form a tripartite complex with protein, and the use of these agents in the prevention and treatment of diseases with a vascular component, such as solid tumors. Compositions and methods for combination therapy of these diseases, including cancer, as well as therapeutic kits, are also provided.