Sirish C Dave
Pharmacy in Salt Lake City, UT
License number
Utah 291600-1701
Category
Pharmacy
Type
Pharmacist
Address
Address
Salt Lake City, UT
Personal information
See more information about Sirish C Dave at radaris.comName
Address
Phone
7611 Toni Cir, Salt Lake City, UT 84121
7611 Toni Cir, Salt Lake City, UT 84121
Professional information
See more information about Sirish C Dave at trustoria.com
Transmucosal Delivery Of Macromolecular Drugs
Transmucosal Delivery Of Macromolecular Drugs
US Patent:
5516523, May 14, 1996
Filed:
May 16, 1994
Appl. No.:
8/243415
Inventors:
Sonia J. Heiber - Salt Lake City UT
Charles D. Ebert - Salt Lake City UT
Sirish C. Dave - Salt Lake City UT
Charles D. Ebert - Salt Lake City UT
Sirish C. Dave - Salt Lake City UT
Assignee:
TheraTech, Inc. - Salt Lake City UT
International Classification:
A61F 1302
US Classification:
424435
Abstract:
A method and system for mucosally administering a macromolecular drug to mucosa of the oral cavity is shown. The system comprises an inner drug/enhancer/polymer layer having one surface adapted to contact and adhere to the mucosal tissue of the oral cavity and an opposing surface in contact with and adhering to an overlying inert layer. The inner layer contains from about two to sixty percent by weight of a bile salt enhancer, five to sixty five percent by weight of a hydrophilic polymer which is water soluble or swellable and an effective amount of a macromolecular drug having a molecular weight of at least 500 daltons. Polysaccharides, polypeptides and proteins are preferred forms of macromolecular drugs. The bile salt enhancer facilitates the delivery of macromolecules such as low molecular weight heparin and calcitonin. The polymer serves as a plasticizer to prevent the crystallization and/or aggregation of such macromolecular drugs.
Transmucosal Delivery Of Macromolecular Drugs
Transmucosal Delivery Of Macromolecular Drugs
US Patent:
5346701, Sep 13, 1994
Filed:
Feb 22, 1993
Appl. No.:
8/027508
Inventors:
Sonia J. Heiber - Salt Lake City UT
Charles D. Ebert - Salt Lake City UT
Sirish C. Dave - Salt Lake City UT
Charles D. Ebert - Salt Lake City UT
Sirish C. Dave - Salt Lake City UT
Assignee:
TheraTech, Inc. - Salt Lake City UT
International Classification:
A61F 1302
US Classification:
424435
Abstract:
A method and system for mucosally administering a macromolecular drug to mucosa of the oral cavity is shown. The system comprises an inner drug/enhancer/polymer layer having one surface adapted to contact and adhere to the mucosal tissue of the oral cavity and an opposing surface in contact with and adhering to an overlying inert layer. The inner layer contains from about two to sixty percent by weight of a bile salt enhancer, five to sixty five percent by weight of a hydrophilic polymer which is water soluble or swellable and an effective amount of a macromolecular drug having a molecular weight of at least 500 daltons. Polysaccharides, polypeptides and proteins are preferred forms of macromolecular drugs. The bile salt enhancer facilitates the delivery of macromolecules such as low molecular weight heparin and calcitonin. The polymer serves as a plasticizer to prevent the crystallization and/or aggregation of such macromolecular drugs.