Sidney Pestka
Medical Practice in West Caldwell, NJ
License number
New Jersey 25MA02496300
Issued Date
Sep 6, 1971
Expiration Date
Jun 30, 2013
Category
Medical Examiners
Type
Medical Doctor
Address
Address
West Caldwell, NJ
Personal information
See more information about Sidney Pestka at radaris.comName
Address
Phone
Caldwell, NJ
82 Brookside Ave, Caldwell, NJ 07006
100 Jersey Ave, New Brunswick, NJ 08901
60 Paterson St, New Brunswick, NJ 08901
Professional information
Phosphorylated Fusion Proteins
US Patent:
6747131, Jun 8, 2004
Filed:
Nov 28, 2000
Appl. No.:
09/723942
Inventors:
Sidney Pestka - North Caldwell NJ
Assignee:
Pestka Biomedical Laboratories, Inc.
International Classification:
C07K 1456
US Classification:
530352, 435 6951, 435 697, 435325, 435471, 4352523, 4353201, 435 712, 424 141, 536 234, 536 2352, 530351, 530399
Abstract:
Modified proteins, modified interferons s and s, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN--like proteins are provided which carry an identifiable label such as a radio-label. Corresponding phosphorylatable Hu-IFN--like proteins which contain a putative phosphorylation site. DNA sequences which encode a Hu-IFN--like protein and contain a sequence encoding a putative phosphorylatable site. Appropriate expression vectors are used to transform compatible host cells of various microorganisms, such as. Numerous uses for the phosphorylated proteins are disclosed.
Microbial Production Of Mature Human Leukocyte Interferons
US Patent:
6610830, Aug 26, 2003
Filed:
Apr 21, 1981
Appl. No.:
06/256204
Inventors:
David V. Goeddel - Burlingame CA
Sidney Pestka - North Caldwell NJ
Sidney Pestka - North Caldwell NJ
Assignee:
Hoffman-La Roche Inc. - Nutley NJ
Genentech, Inc. - South San Francisco CA
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 1456
US Classification:
530351, 435 6951, 536 2352
Abstract:
Disclosed herein are methods and means of microbially producing, via recombinant DNA technology, mature human leukocyte interferons, useful in the treatment of viral and neoplastic diseases.
Cells Expressing Il-10 Receptor And The Crfb4 Gene Product, An Il-10 Receptor Accessory Protein
US Patent:
5843697, Dec 1, 1998
Filed:
Jul 17, 1996
Appl. No.:
8/683743
Inventors:
Sidney Pestka - North Caldwell NJ
Serguei V. Kotenko - Highland Park NJ
Serguei V. Kotenko - Highland Park NJ
Assignee:
University of Medicine and Dentistry of New Jersey - Piscataway NJ
International Classification:
C12N 1512, C07K 14715, G01N 3353
US Classification:
435 29
Abstract:
The present invention relates to the identification of intracellular signal transduction function for a putative cytokine receptor subunit. In particular, the invention relates to the identification of the signal transduction protein for the interleukin (IL)-10 receptor. Accordingly, the present invention relates to preparing recombinant cells that express the IL-10 receptor and the newly identified IL-10 signal transduction protein, e. g. , for use in screening libraries of compounds for IL-10 agonists and antagonists; to restoring IL-10 function to cells in vivo, e. g. , via gene therapy; and in addition to chimeric proteins comprising this signal transduction protein to agonize IL-10 activity. In specific examples, cells transfected with both the first chain of the IL-10R and the presently identified second chain, termed herein CRFB4, were able to transduce a signal in response to contact with IL-10.
Protein Purification Process And Product
US Patent:
4503035, Mar 5, 1985
Filed:
Feb 14, 1983
Appl. No.:
6/465979
Inventors:
Sidney Pestka - North Caldwell NJ
Menachem Rubinstein - Rimon, IL
Menachem Rubinstein - Rimon, IL
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 4502, C07C10352, C12P 2100
US Classification:
424 85
Abstract:
An improved process for purifying proteins, particularly proteins having molecular weights in excess of 12,000 involves novel applications of high performance liquid chromatography on a preparative scale to provide homogeneous end product in excellent yield. In an embodiment of the process, human interferon is produced as a homogeneous protein.
Human Leukocyte Interferon Hu-Ifn-.Alpha.001
US Patent:
5789551, Aug 4, 1998
Filed:
Jun 10, 1994
Appl. No.:
8/257784
Inventors:
Sidney Pestka - North Caldwell NJ
Assignee:
Pestka Biomedical Laboratories, Inc. - West Caldwell NJ
International Classification:
C07K 1456, C12N 1521
US Classification:
530351
Abstract:
A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and blood-borne malignancies. These new polypeptides are active and will be useful for therapeutic purposes.
Yeast Protein Methyltransferase Hsl7P
US Patent:
2003018, Sep 25, 2003
Filed:
Mar 13, 2003
Appl. No.:
10/239587
Inventors:
Sidney Pestka - North Caldwell NJ, US
Jeffry Cook - Kendall Park NJ, US
Terri Kinzy - Bridgewater NJ, US
Jin-Hyung Lee - Piscataway NJ, US
David Norris - Princeton NJ, US
Brian Pollack - Highland Park NJ, US
Jeffry Cook - Kendall Park NJ, US
Terri Kinzy - Bridgewater NJ, US
Jin-Hyung Lee - Piscataway NJ, US
David Norris - Princeton NJ, US
Brian Pollack - Highland Park NJ, US
International Classification:
A61K038/51, C12N001/18, C12N009/10
US Classification:
435/193000, 424/094500, 435/254210
Abstract:
The present invention relates to yeast protein Hs17p, which is a homologue of Janus kinase binding protein 1, JBP1. Hs17p is a newly characterized protein methyltransferase. The yeast protein Hs17p is a sequence and functional homologue of JBP1 indicating an intricate link between protein methylation and macroscopic changes in yeast morphology.
Constructs For Producing Phosphorylated Fusion Proteins
US Patent:
6225455, May 1, 2001
Filed:
Jan 19, 1995
Appl. No.:
8/375112
Inventors:
Sidney Pestka - North Caldwell NJ
Assignee:
PBL Biomedical Laboratories - New Brunswick NJ
International Classification:
C12N 1520, C12N 1563, C12N 510, C07K 14555
US Classification:
536 234
Abstract:
Modified proteins, modified interferons. alpha. 's and. beta. 's, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-. alpha. -like proteins are provided which carry an identifiable label such as a radio-label. Corresponding phosphorylatable Hu-IFN-. alpha. -like proteins which contain a putative phosphorylation site. DNA sequences which encode a Hu-IFN-. alpha. -like protein and contain a sequence encoding a putative phosphorylatable site. Appropriate expression vectors are used to transform compatible host cells of various microorganisms, such as E. coli. Numerous uses for the phosphorylated proteins are disclosed.
Super Proteins Including Interferons, Interleukins, Et Al.
US Patent:
2003019, Oct 23, 2003
Filed:
Jun 25, 2001
Appl. No.:
09/891093
Inventors:
Sidney Pestka - North Caldwell NJ, US
International Classification:
G01N033/574, C12N005/08, C12P021/02
US Classification:
435/007230, 435/069100, 435/372000
Abstract:
A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and blood-borne malignancies. These new polypeptides are active and will be useful for therapeutic purposes.
Mutant Human Interferons
US Patent:
6299870, Oct 9, 2001
Filed:
Feb 8, 1999
Appl. No.:
9/246447
Inventors:
Sidney Pestka - North Caldwell NJ
Assignee:
PBL Biomedical Laboratories - New Brunswick MA
International Classification:
C07K 14555, A61K 3821, C12N 510, C12N 1520, C12N 1564
US Classification:
424 854
Abstract:
A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and blood-borne malignancies. These new polypeptides are active and will be useful for therapeutic purposes.
Crystalline Human Leukocyte Interferon
US Patent:
4672108, Jun 9, 1987
Filed:
Jul 3, 1985
Appl. No.:
6/751754
Inventors:
Hsiang-Fu Kung - Verona NJ
David L. Miller - Montclair NJ
Sidney Pestka - North Caldwell NJ
David L. Miller - Montclair NJ
Sidney Pestka - North Caldwell NJ
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
C07K 1526, A61K 4502, C12P 2100
US Classification:
530351
Abstract:
The crystallization of human leukocyte interferon is described. In a preferred embodiment crystalline recombinant human leukocyte interferon A (IFL-rA) is prepared.