Inventors:
Benjamin L. Ebert - Brookline MA, US
Andrew M. Stern - Boston MA, US
Peter G. Miller - Boston MA, US
D. Gary Gilliland - Wellesley MA, US
Anne Van Dyk Carpenter - Ashland MA, US
David J. Logan - Maynard MA, US
Joseph Negri - Jamaica Plain MA, US
Nicola Tolliday - Jamaica Plain MA, US
Alykhan Shamji - Somerville MA, US
Siddhartha Mukherjee - New York NY, US
Alison Stewart - Cambridge MA, US
International Classification:
G01N 33/50, A61K 31/4184, A61K 31/395, A61K 31/428, A61K 31/423, A61K 31/704, A61K 31/4745, A61K 31/405, A61K 31/4418, A61K 31/366, A61K 31/22, A61K 31/167, A61K 31/444
US Classification:
514 34, 506 10, 514616, 514395, 514622, 514449, 514367, 514375, 514332, 514619, 514294, 514419, 514277, 514460, 514510
Abstract:
This invention relates to high-throughput, semi-automated methods for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods and uses thereof for treating leukemia.