SHUYI TANG
Broker in Belmont, MA
License number
Massachusetts 9532297
Issued Date
Jun 14, 2014
Expiration Date
Dec 11, 2016
Type
Salesperson
Address
Address
Belmont, MA 02478
Professional information
Novel Pyrazolo[1,5-A]Pyrimidine Derivatives As Mtor Inhibitors
US Patent:
2013015, Jun 13, 2013
Filed:
Aug 22, 2011
Appl. No.:
13/818177
Inventors:
Lianyun Zhao - Blue Bell PA, US
Duan Liu - Arlington MA, US
Shuyi Tang - Belmont MA, US
Amit K. Mandal - Shrewsbury MA, US
Umar Faruk Mansoor - Framingham MA, US
Lalanthi Dilrukshi Vitharana - Somerville MA, US
Panduranga Adulla P. Reddy - Walpole MA, US
M. Arshad Siddiqui - Newton MA, US
Duan Liu - Arlington MA, US
Shuyi Tang - Belmont MA, US
Amit K. Mandal - Shrewsbury MA, US
Umar Faruk Mansoor - Framingham MA, US
Lalanthi Dilrukshi Vitharana - Somerville MA, US
Panduranga Adulla P. Reddy - Walpole MA, US
M. Arshad Siddiqui - Newton MA, US
Assignee:
MERCK SHARP & DOHME CORP. - Rahway NJ
International Classification:
C07D 487/04, A61K 31/519, A61K 31/5377, A61K 45/06
US Classification:
5142332, 544282, 5142593, 544117
Abstract:
The present invention relates to certain pyrazolo[1,5-a]pyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrimidine compounds.
Pyrazolo[1,5-A]Pyrimidine Compounds As Mtor Inhibitors
US Patent:
2012032, Dec 20, 2012
Filed:
Jan 18, 2011
Appl. No.:
13/520274
Inventors:
M. Arshad Siddiqui - Newton MA, US
Yang Nan - Malden MA, US
Mehul F. Patel - Blue Bell PA, US
Panduranga Adulla P. Reddy - Walpole MA, US
Umar Faruk Mansoor - Framingham MA, US
Zhaoyang Meng - Lansdale PA, US
Lalanthi Dilrukshi Vitharana - Somerville MA, US
Lianyun Zhao - Blue Bell PA, US
Amit K. Mandal - Shrewsbury MA, US
Duan Liu - Arlington MA, US
Shuyi Tang - Belmont MA, US
Andrew McRiner - Melrose MA, US
David B. Belanger - Cambridge MA, US
Patrick J. Curran - Saugus MA, US
Chaoyang Dai - Acton MA, US
Angie R. Angeles - Boston MA, US
Liping Yang - Arlington MA, US
Matthew Hersh Daniels - Cambridge MA, US
Yang Nan - Malden MA, US
Mehul F. Patel - Blue Bell PA, US
Panduranga Adulla P. Reddy - Walpole MA, US
Umar Faruk Mansoor - Framingham MA, US
Zhaoyang Meng - Lansdale PA, US
Lalanthi Dilrukshi Vitharana - Somerville MA, US
Lianyun Zhao - Blue Bell PA, US
Amit K. Mandal - Shrewsbury MA, US
Duan Liu - Arlington MA, US
Shuyi Tang - Belmont MA, US
Andrew McRiner - Melrose MA, US
David B. Belanger - Cambridge MA, US
Patrick J. Curran - Saugus MA, US
Chaoyang Dai - Acton MA, US
Angie R. Angeles - Boston MA, US
Liping Yang - Arlington MA, US
Matthew Hersh Daniels - Cambridge MA, US
International Classification:
A61K 31/519, A61K 31/5377, C07D 487/08, A61K 31/55, A61P 35/00, C07D 498/08, A61K 31/5386, C07D 513/08, A61K 31/547, C07D 491/147, C07D 487/04, C07D 471/08
US Classification:
514215, 544281, 5142593, 544117, 5142332, 540580, 544105, 5142305, 544 47, 5142242, 514249, 51425216
Abstract:
The present invention provides Pyrazolopyrimidine Compounds of Formula (I):wherein L, T, Z, U, V, W, R, R, R, R, and m are as defined herein, and pharmaceutically acceptable salts of such Pyrazolopyrimidine Compounds. The Pyrazolopyrimidine Compounds are useful in the treatment of cancer and other diseases or disorders wherein mTOR is deregulated.
Pyrazolo[1,5-A]Pyrimidine Derivatives As Mtor Inhibitors
US Patent:
8591943, Nov 26, 2013
Filed:
Apr 8, 2010
Appl. No.:
13/263193
Inventors:
Yongqi Deng - Newton MA, US
Binyuan Sun - Chestnut Hill MA, US
Hongbo Zeng - Westford MA, US
Matthew Richards - Somerville MA, US
Cliff C. Cheng - Cambridge MA, US
Yinyan Zhao - Rockville MD, US
Andrew McRiner - Melrose MA, US
Zhaoyang Meng - Lansdale PA, US
Yang Nan - Lansdale PA, US
Mehul F. Patel - Willow Grove PA, US
Iwona E. Wrona - Sharon MA, US
Panduranga Adulla Reddy - Walpole MA, US
Brian M. Eklov - Kalamazoo MI, US
Shuyi Tang - Belmont MA, US
Duan Liu - Arlington MA, US
Amit K. Mandal - Shrewsbury MA, US
Lianyun Zhao - Blue Bell PA, US
M. Arshad Siddiqui - Newton MA, US
Binyuan Sun - Chestnut Hill MA, US
Hongbo Zeng - Westford MA, US
Matthew Richards - Somerville MA, US
Cliff C. Cheng - Cambridge MA, US
Yinyan Zhao - Rockville MD, US
Andrew McRiner - Melrose MA, US
Zhaoyang Meng - Lansdale PA, US
Yang Nan - Lansdale PA, US
Mehul F. Patel - Willow Grove PA, US
Iwona E. Wrona - Sharon MA, US
Panduranga Adulla Reddy - Walpole MA, US
Brian M. Eklov - Kalamazoo MI, US
Shuyi Tang - Belmont MA, US
Duan Liu - Arlington MA, US
Amit K. Mandal - Shrewsbury MA, US
Lianyun Zhao - Blue Bell PA, US
M. Arshad Siddiqui - Newton MA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 9/127, A61K 39/395, A61K 31/554, A61K 31/541, A61K 31/5377, A61K 38/50, A61K 31/553, A61K 33/24, A61K 31/704, A61K 31/551, A61K 31/538, A61K 31/519
US Classification:
424450, 424 946, 4241381, 424623, 424649, 4241331, 51425216, 5142332, 5142555, 51421115, 5142522, 514218, 51421016, 514 34, 5142285, 514249, 5142593, 5142305, 51421018
Abstract:
The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.
Thiazole Derivatives As Protein Kinase Inhibitors
US Patent:
8476278, Jul 2, 2013
Filed:
Oct 27, 2008
Appl. No.:
12/738487
Inventors:
Panduranga Adulla P. Reddy - Walpole MA, US
Tzu T. Wong - Belmont MA, US
Lianyun Zhao - Burlington MA, US
Shuyi Tang - Belmont MA, US
Marc A. Labroli - Moorestown NJ, US
Timothy J. Guzi - Sudbury MA, US
M. Arshad Siddiqui - Newton MA, US
Tzu T. Wong - Belmont MA, US
Lianyun Zhao - Burlington MA, US
Shuyi Tang - Belmont MA, US
Marc A. Labroli - Moorestown NJ, US
Timothy J. Guzi - Sudbury MA, US
M. Arshad Siddiqui - Newton MA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/496, C07D 417/14, A61K 31/427, A61K 31/551, A61K 31/5377, C07D 413/14, C07D 417/12, C07D 471/10
US Classification:
5142531, 514218, 5142335, 514278, 540575, 544 60, 544 61, 544 62, 544121, 544131, 544133, 544364, 546 16
Abstract:
The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.
Heterocyclic Amide Compounds As Protein Kinase Inhibitors
US Patent:
8293747, Oct 23, 2012
Filed:
Jul 17, 2008
Appl. No.:
12/669334
Inventors:
Panduranga Adulla P. Reddy - Walpole MA, US
Lianyun Zhao - Burlington MA, US
Praveen K. Tadikonda - Norwood MA, US
Tzu Tshin Wong - Belmont MA, US
Shuyi Tang - Belmont MA, US
Luis E. Torres - Medford MA, US
Timothy J. Guzi - Sudbury MA, US
M. Arshad Siddiqui - Newton MA, US
Lianyun Zhao - Burlington MA, US
Praveen K. Tadikonda - Norwood MA, US
Tzu Tshin Wong - Belmont MA, US
Shuyi Tang - Belmont MA, US
Luis E. Torres - Medford MA, US
Timothy J. Guzi - Sudbury MA, US
M. Arshad Siddiqui - Newton MA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/506, C07D 401/14, A61K 31/496, A61K 31/497, A61K 31/519, C07D 405/14, C07D 409/14, C07D 413/14, C07D 417/14, C07D 471/04, C07D 487/04, C07D 491/04
US Classification:
51425218, 544295, 544121, 544263, 544280, 544357, 544362, 544363, 544364, 546194
Abstract:
The present invention relates to novel heterocyclic amide compounds of Formula I: as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease.