SHOUJUN CHEN
Broker in Bedford, MA
License number
Massachusetts 9515621
Issued Date
Apr 14, 2010
Expiration Date
Jul 18, 2018
Type
Salesperson
Address
Address
Bedford, MA 01730
Professional information
Synthesis Of Bis(Thio-Hydrazide Amide) Salts
US Patent:
7709683, May 4, 2010
Filed:
May 11, 2006
Appl. No.:
11/432307
Inventors:
Shoujun Chen - Bedford MA, US
Zhi-Qiang Xia - Acton MA, US
Zhi-Qiang Xia - Acton MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
C07C 241/02
US Classification:
564148, 564149, 564151, 564 74
Abstract:
A method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide), an organic solvent and a base to form a bis(thio-hydrazide amide) solution; and combining the solution and methyl tert-butyl ether, thereby precipitating a disalt of the bis(thio-hydrazide amide). In some embodiments, a method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide) and an organic solvent selected from methanol, ethanol, acetone, and methyl ethyl ketone to make a mixture; adding at least two equivalents of a base selected from sodium hydroxide, potassium hydroxide, sodium methoxide, potassium methoxide, sodium ethoxide and potassium ethoxide to the mixture, thereby forming a solution; and combining the solution and methyl tert-butyl ether to precipitate the disalt of the bis(thio-hydrazide amide). The disclosed methods do not require lyophilization and the solvents used in the process can be more readily removed to low levels consistent with pharmaceutically acceptable preparation.
Bis(Thio-Hydrazide Amide) Salts For Treatment Of Cancers
US Patent:
7385084, Jun 10, 2008
Filed:
Jun 20, 2005
Appl. No.:
11/157213
Inventors:
Keizo Koya - Chestnut Hill MA, US
Lijun Sun - Harvard MA, US
Elena Kostik - Arlington MA, US
Farid Vaghefi - Watertown MA, US
Shoujun Chen - Bedford MA, US
Noriaki Tatsuta - Lexington MA, US
Guiqing Liang - Concord MA, US
Takayo Inoue - Malden MA, US
Zhi-Qiang Xia - Acton MA, US
Lijun Sun - Harvard MA, US
Elena Kostik - Arlington MA, US
Farid Vaghefi - Watertown MA, US
Shoujun Chen - Bedford MA, US
Noriaki Tatsuta - Lexington MA, US
Guiqing Liang - Concord MA, US
Takayo Inoue - Malden MA, US
Zhi-Qiang Xia - Acton MA, US
Assignee:
Synta Pharmaceutical Corp. - Lexington MA
International Classification:
C07C 327/38, A61K 31/16
US Classification:
564 74, 514422, 514599, 548518
Abstract:
Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I):Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R-Rare independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or Rand Rtaken together with the carbon and nitrogen atoms to which they are bonded, and/or Rand Rtaken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. Z is —O or —S. M is a pharmaceutically acceptable monovalent cation and M is a pharmaceutically acceptable divalent cation. Also, disclosed are pharmaceutical compositions comprising a bis(thio-hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis(thio-hydrazide amide) disalt described above.
Fused Ring Compounds For Inflammation And Immune-Related Uses
US Patent:
2008013, Jun 5, 2008
Filed:
Sep 25, 2007
Appl. No.:
11/861278
Inventors:
Quinglin Che - Foxboro MA, US
Nha Huu Vo - Southborough MA, US
Shoujun Chen - Bedford MA, US
Nha Huu Vo - Southborough MA, US
Shoujun Chen - Bedford MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A61K 31/498, C07D 513/04, C07D 417/02, C07D 239/70, A61P 37/06, A61P 29/00, A61K 31/435, C07D 487/00, A61K 31/429
US Classification:
514250, 548151, 5462701, 544249, 514366, 514338, 514267, 544344
Abstract:
The invention relates to certain fused ring compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
Synthetic Derivatives
US Patent:
2003023, Dec 25, 2003
Filed:
Feb 27, 2003
Appl. No.:
10/376800
Inventors:
Shoujun Chen - Bedford MA, US
Lijun Sun - Harvard MA, US
Joel McCleary - The Plains VA, US
Lijun Sun - Harvard MA, US
Joel McCleary - The Plains VA, US
International Classification:
A61K031/366, A61K031/4433, A61K031/4025, C 07D 4 5/02, C07D309/38, C07D309/30
US Classification:
514/460000, 549/292000, 549/293000, 549/294000, 514/336000, 514/422000, 546/282400, 548/517000
Abstract:
This invention features a 5,6-dihydro-2-pyrone compound of formula (I), wherein Ris H, OH, or C˜Calkoxyl; and Ris 2-phenyl ethyl, 2-phenyl ethenyl, 2-heteroaryl ethyl, or 2-heteroaryl ethenyl; in which the phenyl or the heteroaryl is optionally mono-, di-, or tri-substituted with R, R, or R; each of R, R, and R, independently, is Cl, F, Br, I, CN, C˜Calkyl, C˜Calkoxyl, C˜Calkenyloxy, C˜Ccycloalkoxyl, C˜Ccycloalkyl alkoxyl, C˜Calkoxy alkoxyl, or C˜Calkoxy carbonyl.
Tetrazolyl-Tetrahydropyridine Compounds For Inflammation And Immune-Related Uses
US Patent:
2013028, Oct 31, 2013
Filed:
Nov 9, 2011
Appl. No.:
13/884323
Inventors:
Gary Bohnert - Wilmington MA, US
Shoujun Chen - Bedford MA, US
Shoujun Chen - Bedford MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
C07D 401/14
US Classification:
514333, 546256, 435375, 544405
Abstract:
The invention relates to certain compounds according to formula (I): or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
Compounds For Inflammation And Immune-Related Uses
US Patent:
2014004, Feb 13, 2014
Filed:
Oct 15, 2013
Appl. No.:
14/054610
Inventors:
Junyi Zhang - Lexington MA, US
Shoujun Chen - Bedford MA, US
Lijun Sun - Harvard MA, US
Shoujun Chen - Bedford MA, US
Lijun Sun - Harvard MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
C07D 401/10, C07D 417/10, C07D 401/12, C07D 417/14
US Classification:
51425505, 544405
Abstract:
The invention relates to certain compounds according to Formula (I):or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders and immune disorders.
Compounds For Inflammation And Immune-Related Uses
US Patent:
2011005, Mar 3, 2011
Filed:
Jan 7, 2009
Appl. No.:
12/811402
Inventors:
Qinglin Che - Foxboro MA, US
Nha Huu Vo - Southborough MA, US
Shoujun Chen - Bedford MA, US
Lijun Sun - Harvard MA, US
Nha Huu Vo - Southborough MA, US
Shoujun Chen - Bedford MA, US
Lijun Sun - Harvard MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A61K 31/56, C07D 333/80, C07D 409/10, C07D 277/60, C07D 221/16, C07D 401/10, C07D 241/54, C07D 223/24, A61K 31/381, A61K 31/4436, A61K 31/4178, A61K 31/428, A61K 31/435, A61K 31/498, A61K 31/55, C12N 5/078, C12N 5/071, C12N 5/0783, C12N 5/0781, A61P 29/00, A61P 19/02, A61P 19/08, A61P 11/06, A61P 17/06, A61P 17/00, A61P 25/16, A61P 37/06, A61P 9/10, A61P 35/00, A61P 3/00, A61P 25/00, A61P 25/28, A61P 37/08, A61P 43/00
US Classification:
4242781, 549 43, 5462811, 5483114, 548150, 546 93, 544344, 540587, 514443, 514337, 514397, 514366, 514290, 514250, 514217, 514171, 435375
Abstract:
The invention relates to certain fused ring compounds, or pharmaceutically acceptable salts thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
Compounds For Treating Proliferative Disorders
US Patent:
8609720, Dec 17, 2013
Filed:
Aug 20, 2007
Appl. No.:
12/310304
Inventors:
Shoujun Chen - Bedford MA, US
Keizo Koya - Chestnut Hill MA, US
Zachary Demko - Somerville MA, US
Lijun Sun - Harvard MA, US
Keizo Koya - Chestnut Hill MA, US
Zachary Demko - Somerville MA, US
Lijun Sun - Harvard MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A61K 31/15, C07C 243/14, C07C 243/42
US Classification:
514482, 564 79, 564 81
Abstract:
Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
Heterocycle-Aryl Compounds For Inflammation And Immune-Related Uses
US Patent:
8435996, May 7, 2013
Filed:
Jul 31, 2008
Appl. No.:
12/452979
Inventors:
Shoujun Chen - Bedford MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A01N 43/80, A01N 43/50, A01N 43/40, A01N 43/82, A61K 31/42, A61K 31/425, A61K 31/415, A61K 31/497, A61K 31/435, A61K 31/41
US Classification:
5142521, 514277, 514364, 514372, 514378, 514396
Abstract:
The invention relates to compounds that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
Compounds For The Treatment Of Proliferative Disorders
US Patent:
8399435, Mar 19, 2013
Filed:
Oct 7, 2011
Appl. No.:
13/269042
Inventors:
Lijun Sun - Harvard MA, US
Jun Jiang - Norwood MA, US
Christopher Borella - Bedford MA, US
Shoujun Chen - Bedford MA, US
Keizo Koya - Chestnut Hill MA, US
Jun Jiang - Norwood MA, US
Christopher Borella - Bedford MA, US
Shoujun Chen - Bedford MA, US
Keizo Koya - Chestnut Hill MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A61K 31/675, A61K 31/4439, A61K 31/4709, A61K 31/4725, A61P 35/00, C07D 275/02, C07D 261/08, C07D 417/10, C07F 9/09, C12N 5/07
US Classification:
514 92, 514372, 514378, 514342, 514307, 548206, 548247, 548119, 546148, 546167
Abstract:
The invention relates to compounds of structural formula (I):or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein R, R, and Rare defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.