DR. SHIH-WEN HUANG, MD
Medical Practice at Archer Rd, Gainesville, FL

7270974, Sep 18, 2007

Mar 16, 1999

09/936954

Parker Small - Gainesville FL, US
Shih-Wen Huang - Gainesville FL, US

University of Florida Research Foundation, Inc. - Gainsville FL

C12Q 1/44

435 19, 435 34, 435811

A method and device for rapidly, non-invasively and inexpensively differentiating between allergic rhinitis, upper respiratory tract viral infection and bacterial sinusitis, comprising a support strip upon which is fixed discrete indicators of pH, protein content, nitrite content, esterase activity, and eosinophil content of a sample with which said reagent test strip is contacted. Contact of a nasal secretion with the device of this invention permits differentiation between allergic, bacterial and viral conditions, based on pH, protein content, esterase activity, nitrite content, and eosinophil content.

6551791, Apr 22, 2003

Jun 19, 2000

09/597360

Parker Small - Gainesville FL
Shih-Wen Huang - Gainesville FL
Ronald Kudla - Gainesville FL

University of Florida - Gainesville FL

C12Q 144

435 19, 435 34, 436811

A method and device for rapidly, non-invasively and inexpensively differentiating between allergic rhinitis, upper respiratory tract viral infection and bacterial sinusitis, comprising a support strip upon which is fixed discrete indicators of pH, protein content, nitrite content, leukocyte esterase activity, and eosinophil content or other measure of a substance found in allergic secretions, such as TAME esterase, of a sample with which said reagent test strip is contacted. Contact of a nasal secretion with the device of this invention permits differentiation between allergic, bacterial and viral conditions, based on pH, protein content, leukocyte esterase activity, nitrite content, eosinophil content and TAME esterase activity. The invention further provides a novel means for collecting nasal secretions to facilitate differential diagnosis of sinusitis, upper respiratory tract viral infection and allergic rhinitis.

6764849, Jul 20, 2004

Dec 13, 2001

10/015525

Parker Small - Gainesville FL
Shih-Wen Huang - Gainesville FL
Ronald Kudla - Gainesville FL

Univeristy of Florida - Gainesville FL

C12N 134

4352881, 435 19, 4353053

A device for collecting nasal secretions that comprises a container designed to fit about a patients nose. The device comprises a ventilation means to allow the patient to blow their nose into the container while preventing the undesired dispersion of nasal secretion onto the patient and their surrounding environment.

5910421, Jun 8, 1999

Mar 25, 1996

8/621557

Parker A. Small - Gainesville FL
Shih-Wen Huang - Gainesville FL

University of Florida - Gainesville FL

C12Q 144

435 19

This method for non-invasively, rapidly and simply distinguishing between allergies, viral infections and sinusitis involves testing nasal secretions, preferably with commercially available (Ames Division, Miles Laboratories, Inc. , Elkhart, Ind. 46515; or from Boehringer Mannheim Corporation, Advanced Diagnostics, 9115 Hague Road, P. O. Box 50457, Indianapolis, Ind. 46250-0457) or novel, modified reagent test strips. The commercially available strips, also referred to as dipsticks, test for pH, protein, nitrite, glucose, ketone, white blood cell esterase, bilirubin and blood. In the method of this invention, a sample of a patient's nasal secretions is tested and, based on the pH, amount of protein, nitrite, esterase and a measure of eosinophil infiltration, it can quickly be determined if the patient is suffering from an allergy, from a viral infection or a bacterial infection. The method has the potential to supplant much more expensive and invasive clinical procedures.

6967084, Nov 22, 2005

Dec 13, 2001

10/015509

Parker Small - Gainesville FL, US
Shih-Wen Huang - Gainesville FL, US
Ronald Kudla - Gainesville FL, US

University of Flordia - Gainesville FL

C12Q001/44

435 19, 435 34, 435975

A kit for detecting upper respiratory conditions. The kit includes a container for collecting nasal secretions. The kit further comprises a means for providing a differential readout upon contact with the nasal secretions.

6855491, Feb 15, 2005

Dec 13, 2001

10/015520

Parker Small - Gainesville FL, US
Shih-Wen Huang - Gainesville FL, US
Ronald Kudla - Gainesville FL, US

University of Florida - Gainesville FL

C12Q001/00

435 4, 435 19, 422 56, 422 58

A device for detecting upper respiratory conditions. The device includes a support upon which are fixed discrete indicators of pH, protein content, nitrite content and/or leukocyte esterase activity. The device further comprises a container to facilitate collection of nasal secretion sample in order to test for different upper respiratory conditions.

2004002, Feb 12, 2004

Jul 30, 2002

10/209396

Parker Small - Gainesville FL, US
Darla Gaskins - Gainesville FL, US
Kenneth Rand - Gainesville FL, US
Shih-Wen Huang - Gainesville FL, US

C12Q001/44, C12Q001/37

435/019000, 435/023000

A novel diagnostic system for rapidly, non-invasively and inexpensively differentiating sputum from saliva. The disclosed methods utilize a test strip or stick assay, or other similar assays, for detecting the presence of leukocyte esterase which correlates to the presence of sputum in a patient sample.

6951730, Oct 4, 2005

Dec 13, 2001

10/015521

Parker Small - Gainesville FL, US
Shih-Wen Huang - Gainesville FL, US
Ronald Kudla - Gainesville FL, US

University of Florida Research Foundation, Inc. - Gainesville FL

C12Q001/44

435 19, 435 34, 436811

A method for detecting upper respiratory conditions. The method includes implementation of a device upon which are fixed discrete indicators of pH, protein content, nitrite content and/or leukocyte esterase activity.