SHENGJIN JIN
Broker in Acton, MA
License number
Massachusetts 9519138
Issued Date
Mar 12, 2011
Expiration Date
Mar 1, 2016
Type
Salesperson
Address
Address
Acton, MA 01720
Professional information
Process For Preparing Purified Drug Conjugates
US Patent:
2013028, Oct 24, 2013
Filed:
Feb 25, 2013
Appl. No.:
13/776097
Inventors:
Yong WANG - North Attleboro MA, US
Shengjin JIN - Acton MA, US
Deborah H. MESHULAM - Brookline MA, US
Godfrey W. AMPHLETT - Cambridge MA, US
Shengjin JIN - Acton MA, US
Deborah H. MESHULAM - Brookline MA, US
Godfrey W. AMPHLETT - Cambridge MA, US
International Classification:
A61K 47/48
US Classification:
5303919
Abstract:
The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
Process For Manufacturing Conjugates Of Improved Homogeneity
US Patent:
2012025, Oct 11, 2012
Filed:
Mar 29, 2012
Appl. No.:
13/434586
Inventors:
Shengjin JIN - Acton MA, US
Assignee:
IMMUNOGEN, INC. - Waltham MA
International Classification:
C07K 17/02
US Classification:
5303919, 5303911
Abstract:
The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved homogeneity comprising performing the modification reaction at a lower temperature. The inventive processes comprise contacting a cell-binding agent with a bifunctional crosslinking reagent at a temperature of about 15° C. or less to covalently attach a linker to the cell-binding agent and thereby prepare a mixture comprising cell-binding agents having linkers bound thereto.
Process For Preparing Purified Drug Conjugates
US Patent:
2011016, Jul 7, 2011
Filed:
Dec 22, 2010
Appl. No.:
12/975695
Inventors:
Yong DAI - Northborough MA, US
Yong WANG - Wayland MA, US
Shengjin JIN - Acton MA, US
Deborah MESHULAM - Brookline MA, US
Godfrey AMPHLETT - Cambridge MA, US
Ravi CHARI - Newton MA, US
Wei ZHANG - Wayne PA, US
Yong WANG - Wayland MA, US
Shengjin JIN - Acton MA, US
Deborah MESHULAM - Brookline MA, US
Godfrey AMPHLETT - Cambridge MA, US
Ravi CHARI - Newton MA, US
Wei ZHANG - Wayne PA, US
Assignee:
ImmunoGen, Inc. - Waltham MA
International Classification:
C07K 1/107
US Classification:
530303, 530351, 530324, 530399, 530380, 5303917, 5303919
Abstract:
The invention provides processes for preparing a cell-binding agent chemically coupled to a drug. A first process comprises covalently attaching a linker to a cell-binding agent, an optional purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, and optional holding steps. A second process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, holding steps, and optionally a tangential flow filtration (TFF) step.
Process For Preparing Purified Drug Conjugates
US Patent:
2007004, Mar 1, 2007
Filed:
Aug 14, 2006
Appl. No.:
11/503781
Inventors:
Yong Dai - Newton MA, US
Yong Wang - North Attleboro MA, US
Shengjin Jin - Acton MA, US
Deborah Meshulam - Brookline MA, US
Godfrey Amphlett - Cambridge MA, US
Yong Wang - North Attleboro MA, US
Shengjin Jin - Acton MA, US
Deborah Meshulam - Brookline MA, US
Godfrey Amphlett - Cambridge MA, US
Assignee:
ImmunoGen, Inc. - Cambridge MA
International Classification:
A61K 39/395, G01N 33/53, C07K 16/28
US Classification:
424145100, 424155100, 424178100, 530388220, 530388230, 435007100
Abstract:
The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
Process For Preparing Purified Drug Conjugates
US Patent:
8383122, Feb 26, 2013
Filed:
Oct 8, 2010
Appl. No.:
12/901039
Inventors:
Yong Dai - Newton MA, US
Yong Wang - North Attleboro MA, US
Shengjin Jin - Acton MA, US
Deborah H. Meshulam - Brookline MA, US
Godfrey W. Amphlett - Cambridge MA, US
Yong Wang - North Attleboro MA, US
Shengjin Jin - Acton MA, US
Deborah H. Meshulam - Brookline MA, US
Godfrey W. Amphlett - Cambridge MA, US
Assignee:
ImmunoGen, Inc. - Waltham MA
International Classification:
A61K 39/395, G01N 33/53, C07K 16/28
US Classification:
4241781, 4241451, 4241551, 4241831, 5303877, 53038823, 5303917
Abstract:
The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.