SHEILA MARGARET NOLAN
Medical Practice in Pleasantville, NY
License number
Pennsylvania MD428132
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Pleasantville, NY 10570
Pennsylvania
Pennsylvania
Professional information
Attenuated Human Parainfluenza Virus, Methods And Uses Thereof
US Patent:
2013005, Feb 28, 2013
Filed:
Jan 10, 2006
Appl. No.:
13/501447
Inventors:
Mario H. Skiadopoulos - Potomac MD, US
Peter L. Collins - Silver Spring MD, US
Sheila Nolan - Pleasantville NY, US
Peter L. Collins - Silver Spring MD, US
Sheila Nolan - Pleasantville NY, US
Assignee:
THE GOVERNMENT OF THE US, REPRESENTED BY THE SECRETARY , DEPT. OF HEALTH AND HUMAN SERVICES - Rockville MD
International Classification:
C12N 7/04, C12N 7/01
US Classification:
435236, 4352351
Abstract:
The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein. In some embodiments, recombinant paramyxovirus have at least one temperature sensitive mutation and one non-temperature sensitive mutation. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.