DR. SHARON CHEN, PSY.D.
Social Work at Colorado Blvd, Pasadena, CA
License number
California PSY21946
Category
Social Work
Type
Clinical
Address
Address
595 E Colorado Blvd, Pasadena, CA 91101
Phone
(626) 298-8068
Professional information
Sharon Y Chen, Pasadena CA
Specialties:
Psychologist
Address:
595 E Colorado Blvd, Pasadena, CA 91101
Sharon Chen, Pasadena CA
Specialties:
Clinical Psychology
Address:
595 E Colorado Blvd, Pasadena 91101
(626) 298-8068 (Phone)
(626) 298-8068 (Phone)
Languages:
English
Two Step Enzymatic Acylation
US Patent:
6261813, Jul 17, 2001
Filed:
Nov 23, 1998
Appl. No.:
9/198096
Inventors:
Yuri L. Khmelnitsky - Coralville IA
Cheryl L. Budde - Coralville IA
John M. Arnold - Coralville IA
Joseph O. Rich - Iowa City IA
Sharon S. Chen - Pasadena CA
Alexander Ya. Usyatinsky - Coralville IA
Douglas S. Clark - Orinda CA
Jonathan S. Dordick - Schenectady NY
Cheryl L. Budde - Coralville IA
John M. Arnold - Coralville IA
Joseph O. Rich - Iowa City IA
Sharon S. Chen - Pasadena CA
Alexander Ya. Usyatinsky - Coralville IA
Douglas S. Clark - Orinda CA
Jonathan S. Dordick - Schenectady NY
Assignee:
Albany Molecular Research, Inc. - Albany NY
International Classification:
C12P 762
US Classification:
435135
Abstract:
A method for derivatizing a compound having a hydroxyl group by back to back acylation is provided. The compound is acylated with a bifunctional acyl donor in the presence of a hydrolase to form an activated acyl ester or carbonate. Preferably the bifunctional acylating donor is a di(vinyl) ester or carbonate. The activated acyl ester or carbonate is then used to acylate a nucleophile in the presence of a lipase. The method of the invention provides regioselective enzymatic acylation of the base compound.