Inventors:
Bastiaan Nuijen - Amsterdam, NL
Ernie Pfadenhauer - Irvine CA, US
Jos H. Beijnen - Amsterdam, NL
Luigi Lenaz - Newton PA, US
Shanta Chawla - Irvine CA, US
Mario Beer - San Clemente CA, US
International Classification:
A61M 37/00, A61P 35/00, A61K 31/404
Abstract:
Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, bladder cancer treatments include the intravesical administration of apaziquone immediately following transurethral resection. Also disclosed are therapeutic compositions comprising an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.