Inventors:
Gary R. Fanger - Mill Creek WA, US
Shannon Kathleen Hirst - Kirkland WA, US
Davin C. Dillon - Issaquah WA, US
Teresa M. Foy - Snoqualmie WA, US
Raymond L. Houghton - Bothell WA, US
David H. Persing - San Martin CA, US
Michael D. Kalos - Pasadena CA, US
Assignee:
CORIXA CORPORATION - Hamilton MT
International Classification:
A61K 39/395, C07H 21/04, C07K 2/00, C12N 15/63, C12N 5/00, C07K 16/00, A61K 35/12, C12Q 1/68, A61P 35/04, A61K 39/00, G01N 33/574, C07K 14/00, C12N 5/02, A61K 38/00, A61K 31/7088
US Classification:
4241381, 536 231, 536 245, 530300, 4353201, 435325, 5303877, 435 723, 530350, 435375, 514 2, 514 44, 424 9321, 424 9371, 4241851, 4241921, 4242771, 435 6
Abstract:
Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.