SETH WARNER DONAHUE
Pharmacy in Houghton, MI
License number
Michigan 5304000287
Issued Date
Nov 24, 2009
Expiration Date
Jun 30, 2012
Category
Pharmacy
Type
CS - Research Lab
Address
Address
Houghton, MI 49931
Professional information
Black Bear Parathyroid Hormone And Methods Of Using Black Bear Parathyroid Hormone
US Patent:
2012024, Sep 27, 2012
Filed:
Dec 7, 2009
Appl. No.:
13/514362
Inventors:
Seth W. Donahue - Houghton MI, US
Assignee:
MICHIGAN TECHNOLOGICAL UNIVERSITY - Houghton MI
International Classification:
A61K 38/29, C12N 5/077, A61P 19/10, C07H 21/04, A61K 33/06, A61P 19/08, C07K 14/635, C07K 16/26
US Classification:
424682, 530324, 514 118, 435375, 5303879, 536 2351
Abstract:
Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; also provided are antibodies directed against black bear parathyroid hormone (PTH) and functional fragments thereof.
Cell Culture Method And Apparatus For Mechanically Stimulating Cells
US Patent:
2006023, Oct 19, 2006
Filed:
Apr 18, 2005
Appl. No.:
11/108403
Inventors:
Seth Donahue - Houghton MI, US
Assignee:
Board of Control of Michigan Technological University - Houghton MI
International Classification:
C12M 3/00
US Classification:
435293100, 435395000
Abstract:
A cell culture assembly and a method for culturing cells that provide mechanical stimulation to cells. The cell culture assembly can include a flow chamber positioned in a fluid path and a support comprising cells positioned within the flow chamber to expose the cells to the fluid path. The cell culture assembly can further include a means for producing a steady flow of fluid in the fluid path, and a means for producing an oscillatory flow of fluid in the fluid path simultaneously with producing the steady flow of fluid in the fluid path to mechanically stimulate the cells. The method can include transporting fluid in the fluid path at a substantially steady flow rate, and transporting fluid in the fluid path at a substantially oscillatory flow rate simultaneously with transporting fluid in the fluid path at a substantially steady flow rate.
Methods Of Using Black Bear Parathyroid Hormone
US Patent:
7994129, Aug 9, 2011
Filed:
Nov 13, 2006
Appl. No.:
11/559285
Inventors:
Seth W. Donahue - Houghton MI, US
Assignee:
Michigan Technological University - Houghton MI
International Classification:
A61K 38/00, A61K 38/29
US Classification:
514 118, 514 167, 514 168, 514 169, 514 171
Abstract:
Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; also provided are antibodies directed against black bear parathyroid hormone (PTH) and functional fragments thereof.