SEOK HO LEE
Pharmacy in Cranford, NJ
License number
Pennsylvania RP037109L
Category
Pharmacy
Type
Pharmacist
Address
Address
2
Cranford, NJ 07016
Pennsylvania
Pennsylvania
Professional information
Indole Diterpene Alkaloid Compounds
US Patent:
5541208, Jul 30, 1996
Filed:
Jan 24, 1994
Appl. No.:
8/186197
Inventors:
Maria L. Garcia - Edison NJ
Robert A. Giacobbe - Lavellette NJ
Otto D. Hensens - Red Bank NJ
Seok H. Lee - Cranford NJ
Owen B. McManus - North Plainfield NJ
Deborah L. Zink - Manalapan NJ
Robert A. Giacobbe - Lavellette NJ
Otto D. Hensens - Red Bank NJ
Seok H. Lee - Cranford NJ
Owen B. McManus - North Plainfield NJ
Deborah L. Zink - Manalapan NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3141, A61K 31395, C07D49822
US Classification:
514379
Abstract:
The present invention relates to compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof which are useful as potassium channel antagonists, particularly Maxi-K channel antagonists, and thus useful in treating Alzheimer's Disease and other cognitive disorders. This invention is also related to a method of making the compound of formula (I).
Biologically Active Compounds
US Patent:
5399587, Mar 21, 1995
Filed:
Dec 13, 1993
Appl. No.:
8/166499
Inventors:
Maria L. Garcia - Edison NJ
Robert A. Giacobbe - Lavellette NJ
Otto D. Hensens - Red Bank NJ
Gregory J. Kaczorowski - Edison NJ
Seok H. Lee - Cranford NJ
Owen B. McManus - North Plainfield NJ
Deborah L. Zink - Manalapan NJ
Robert A. Giacobbe - Lavellette NJ
Otto D. Hensens - Red Bank NJ
Gregory J. Kaczorowski - Edison NJ
Seok H. Lee - Cranford NJ
Owen B. McManus - North Plainfield NJ
Deborah L. Zink - Manalapan NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A01K 3135
US Classification:
514451
Abstract:
The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of the general formula: ##STR1## In addition, a novel microbiological process for producing the claimed compounds is described.