Inventors:
Li-Ru Zhao - Shreveport LA, US
John Kessler - Chicago IL, US
Seema Singhal - Chicago IL, US
Jayesh Mehta - Evanston IL, US
Assignee:
Northwestern University - Evanston IL
International Classification:
A61K 38/00, A61K 38/18
US Classification:
514 11, 514 135, 514 177, 4241451
Abstract:
The present invention relates to the use of stem cell factor (SCF) polypeptide, alone and in combination with granulocyte colony stimulating factor (G-CSF) polypeptide, in the prevention or treatment of injury to the brain after cerebral ischemia or neurological disorder. More particularly, the invention provides methods of improving neurological function and outcome after stroke by the administration of SCF polypeptide, alone and in combination with G-CSF polypeptide. This treatment can be used alone or in combination with other well-known methods of treatment of cerebral ischemia and neurological disorders in a mammal.