Inventors:
Seema A. Ahuja - San Antonio TX
Lynda F. Bonewald - San Antonio TX
Assignee:
Board of Regents, The University of Texas System - Austin TX
International Classification:
A61K 3817
US Classification:
4241851, 424 851, 4241841, 4241921, 4241781, 514 2, 514 8, 514 12, 514885, 530350, 530351
Abstract:
Provided are methods and compositions using one or more CD40 agonists, such as CD40 ligands and/or agonistic anti-CD40 antibodies, to reduce or prevent cell death, or apoptosis, in bone cells. Methods of treating or preventing bone loss, including osteoporosis, as well as methods of reducing or eliminating the bone loss associated with steroid administration are particularly provided. Further disclosed are a variety of therapeutic kits and cocktails.