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Chemo-Sensitivity Assays Using Tumor Cells Exhibiting Persistent Phenotypic Characteristics
US Patent:
7642048, Jan 5, 2010
Filed:
Apr 23, 2007
Appl. No.:
11/785984
Inventors:
Michael Gabrin - Pittsburgh PA, US Stacey Brower - Pittsburgh PA, US Sean McDonald - Pittsburgh PA, US Holly Gallion - Pittsburgh PA, US Payal Nanavati - Pittsburgh PA, US Shara Dawn Rice - Pittsburgh PA, US Anuja Chattopadhyay - Pittsburgh PA, US
Assignee:
Precision Therapeutics Inc. - Pittsburgh PA
International Classification:
C12N 5/02, C12N 5/06, C12Q 1/00, C12N 5/08
US Classification:
435 4, 435374, 435375, 435378, 435379, 435381
Abstract:
The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring the progression of an individual patient malignancy. The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring and for identifying cellular and secreted markers, for screening cells to detect phenotypic and genotypic drift and for predicting chemotherapeutic response of patient tumor cells to at least one therapeutic agent. The assays, methods, tools and systems discussed herein also represent an improved and unified system for monitoring and for screening multiple pharmaceutical agents for efficacy and long term effect as to a specific patient.
Automated System For Selecting Packages From A Cylindrical Storage Area
US Patent:
5880443, Mar 9, 1999
Filed:
Jan 7, 1997
Appl. No.:
8/779918
Inventors:
Sean C. McDonald - Pittsburgh PA Russell E. Myers - Upper St. Clair PA Manoj K. Wangu - Wexford PA
Assignee:
Automated Healthcare - Pittsburgh PA
International Classification:
G06K 1500, G06F 1760, G06F 1700, B65G 100
US Classification:
235375
Abstract:
A system for filling orders, such as prescriptions for patients, having a generally cylindrical storage area for holding packages in known locations. Each location has a unique (r,. theta. ,Y) coordinate. The system also has a computer controlled device for picking packages from selected locations in the storage area. The picker can also be provided with a sensor for detecting rods which hold the packages and relaying the coordinates of the selected locations to the control system. The system may also include a conveyor and a transfer device from the storage area to the conveyor. The picking device deposits the picked packages in the transfer device which directs the packages into a tray on the conveyor. In one embodiment, the contents of each package is a single dosage of medicine.
Automated System For Selecting Packages From A Storage Area
US Patent:
5468110, Nov 21, 1995
Filed:
Aug 25, 1994
Appl. No.:
8/295495
Inventors:
Sean C. McDonald - Pittsburgh PA Ellen J. Hertz - Clemmons NC James A. Smith - Allison Park PA Gregory Toto - Santa Cruz CA
Assignee:
Automated Healthcare, Inc. - Pittsburgh PA
International Classification:
B65G 104
US Classification:
414273
Abstract:
A system for filling orders, such as prescriptions for patients, comprising a device for holding packages. Each package has the same type of contents being held in a predetermined location by the holding device. Each package has an identity which defines the contents therein. The holding device has a plurality of predetermined locations corresponding to a plurality of different types of contents. Additionally, the system is comprised of a device for supplying packages to the holding device. Also, there is a device for picking a package from the holding device that is identified in the order for the purpose of restocking the holding device. The picking device is in communication with the holding device and supplying device. In a preferred embodiment, the contents of each package is a single dosage of medicine.
Portable Nursing Center
US Patent:
5314243, May 24, 1994
Filed:
Dec 4, 1992
Appl. No.:
7/986042
Inventors:
Sean C. McDonald - Pittsburgh PA Robert H. McDonald - Pittsburgh PA Richard R. Lunak - Fair Oaks PA Aldo Zini - Pittsburgh PA
Assignee:
Automated Healthcare, Inc. - Pittsburgh PA
International Classification:
E05B 6500
US Classification:
312215
Abstract:
A portable nursing center has a plurality of selectively locked patient drawers carried in a housing. Each of said drawers are movable between a given open position and a closed position each drawer sized and configured for holding pharmaceutical items which have been prescribed for a specific patient. At least one on demand drawer is also carried by the housing, movable between an open position and a closed position and being sized and configured to hold pharmaceutical and other nursing items used on an as needed basis. A nurse enters a predetermined access data and other data, causing the unit to selectively unlock the appropriate patient drawer or on demand drawer while maintaining other drawers in a locked condition. Whenever the patient is given medicine or otherwise treated the nurse enters or receives information pertinent to that treatment. The unit has a transmitter/receiver to transmit and receive such patient information.
Methods For Assessing Efficacy Of Chemotherapeutic Agents
US Patent:
7575868, Aug 18, 2009
Filed:
Mar 5, 2007
Appl. No.:
11/713662
Inventors:
Paul L. Kornblith - Pittsburgh PA, US Sean McDonald - Pittsburgh PA, US
Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the ability of a chemotherapeutic to destroy cells and the genetic propensity of those cells for resistance. Results obtained using methods of the invention provide insight into the in vivo effectiveness of a therapeutic, and lead to more effective chemotherapeutic treatment.
Automated System For Selecting Packages From A Storage Area
US Patent:
5893697, Apr 13, 1999
Filed:
Mar 26, 1997
Appl. No.:
8/825003
Inventors:
Aldo Zini - Pittsburgh PA Manoj K. Wangu - Wexford PA Sean C. McDonald - Pittsburgh PA
Assignee:
Automated Healthcare, Inc. - Pittsburgh PA
International Classification:
B65G 5900, B65G 6500
US Classification:
414273
Abstract:
A package dispenser that can be used in an automated system for filling orders, such as prescriptions for patients. The dispenser includes a magazine for holding a plurality of packages. The magazine includes a loading end and a dispensing end which has a releasable retainer to keep the loaded packages in the magazine until they are released. Several dispensers may be combined with an automated storage system in which a robot selects packages from storage racks. Then, packages can be simultaneously delivered by the dispensers and the robot. The dispensers may be filled by the robot. The robot and releasable retainer in the dispenser are computer controlled.
Methods For Assessing Efficacy Of Chemotherapeutic Agents
US Patent:
7829288, Nov 9, 2010
Filed:
Jul 28, 2009
Appl. No.:
12/510671
Inventors:
Paul L. Kornblith - Pittsburgh PA, US Sean McDonald - Pittsburgh PA, US
Assignee:
Precision Therapeutics, Inc. - Pittsburgh PA
International Classification:
C12Q 1/68, C07H 21/02, C07H 21/04
US Classification:
435 6, 536 231, 536 243
Abstract:
Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the ability of a chemotherapeutic to destroy cells and the genetic propensity of those cells for resistance. Results obtained using methods of the invention provide insight into the in vivo effectiveness of a therapeutic, and lead to more effective chemotherapeutic treatment.
Methods For Assessing Efficacy Of Chemotherapeutic Agents
US Patent:
8039213, Oct 18, 2011
Filed:
Oct 5, 2010
Appl. No.:
12/898232
Inventors:
Paul L. Kornblith - Pittsburgh PA, US Sean McDonald - Pittsburgh PA, US
Assignee:
Precision Therapeutics, Inc. - Pittsburgh PA
International Classification:
C12Q 1/68, C07H 21/02, C07H 21/04
US Classification:
435 6, 536 231, 536 243
Abstract:
Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the ability of a chemotherapeutic to destroy cells and the genetic propensity of those cells for resistance. Results obtained using methods of the invention provide insight into the in vivo effectiveness of a therapeutic, and lead to more effective chemotherapeutic treatment.