Inventors:
Scott Wepfer - Birmingham AL, US
International Classification:
A61K 38/14, A61P 23/02, A61P 25/04, A61P 25/08, A61P 3/02, A61P 31/04, A61P 31/12, A61K 31/7048, A61K 31/7034, A61K 31/496
US Classification:
424059000, 514626000, 514724000, 514730000, 514781000, 514154000, 514035000, 514008000, 514029000, 514192000, 514200000, 514253080
Abstract:
The topical medicament gel formulation of the present invention includes an anesthetic, an anti-microbial, an oxidant, a nutrient, a diuretic, an opioid, an anti-emetic, an anti-seizure drug, and a non-steroidal anti-inflammatory drug (NSAID), USP in a molecular, as opposed to a salt form, as the active ingredient. Additional constituents illustratively include a skin penetration enhancer and a gelling agent. This invention deals with problems commonly associated with topical application of local medicaments such as: slow onset of action; need for occlusion; and rapid loss of effect due to rapid systemic dispersion. The invention permits enhanced penetration of the medicament and thereby allows for a lesser total dosage of pharmaceutically active ingredient. The use of a lesser total dosage also decreases systemic toxicity.