Inventors:
Jeffrey Scott Albert - Wilmington DE, US
Don Andisik - Wilmington DE, US
James Arnold - Wilmington DE, US
Dean Brown - Wilmington DE, US
Owen Callaghan - Den Bosch, NL
James Campbell - Wilmington DE, US
Robin Arthur Ellis Carr - Bassingbourn, GB
Gianni Chessari - Cambridge, GB
Miles Stuart Congreve - Cambridge, GB
Phil Edwards - Wilmington DE, US
James R. Empfield - Wilmington DE, US
Martyn Frederickson - Cambridge, GB
Gerard M. Koether - Wilmington DE, US
Jennifer Krumrine - Wilmington DE, US
Russ Mauger - Wilmington DE, US
Christopher William Murray - Cambridge, GB
Sahil Patel - Cambridge, GB
Mark Sylvester - Wilmington DE, US
Scott Throner - Wilmington DE, US
Assignee:
AstraZeneca AB - Sodertalje
International Classification:
A61K 31/5377, C07D 239/22, A61K 31/513, C12N 9/99, A61P 25/28, C07D 413/10
US Classification:
5142358, 544321, 514272, 544123, 435184
Abstract:
This invention relates to novel compounds having the structural formula Ia or formula Ib below: (Ia, Ib), and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of Aβ related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.