SCOTT SHORE
Real Estate Commission in Ardmore, PA
License number
Pennsylvania RS271497
Category
Real Estate Commission
Type
Real Estate Salesperson-Standard
Address
Address
Ardmore, PA 19003
Professional information
Multi-Unit Ribozyme Inhibition Of Oncogene Gene Expression
US Patent:
5635385, Jun 3, 1997
Filed:
Sep 15, 1993
Appl. No.:
8/122795
Inventors:
Lance H. Leopold - Philadelphia PA
Scott K. Shore - Ardmore PA
Moole V. R. Reddy - Upper Darby PA
E. Premkumar Reddy - Villanova PA
Scott K. Shore - Ardmore PA
Moole V. R. Reddy - Upper Darby PA
E. Premkumar Reddy - Villanova PA
Assignee:
Temple University-of the Commonwealth System of Higher Education - Philadelphia PA
International Classification:
C12N 508, C12N 516, C12N 1585, C07H 2102
US Classification:
435325
Abstract:
A novel multi-unit ribozyme is provided which is capable of selectively cleaving the mRNA transcript of a hybrid oncogene resulting from a chromosomal translocation. Specialized delivery vehicles such as liposomes, and growth factor conjugates for cellular uptake by receptor-mediated endocytosis, are also described. The multi-unit ribozyme is used for the treatment of neoplasms characterized by expression of the oncogene. In one embodiment, a multi-unit ribozyme is provided which cleaves the mRNA transcript of Philadelphia chromosome-positive cells, thereby blocking production of the tumorigenic p210. sup. bcr-abl fusion protein.