Inventors:
Frank Ivy CARROLL - Research Triangle Park NC, US
Hernan A. Navarro - Research Triangle Park NC, US
Lawrence E. Brieaddy - Research Triangle Park NC, US
Scott P. Runyon - Research Triangle Park NC, US
James B. Thomas - Efland NC, US
Assignee:
RESEARCH TRIANGLE INSTITUTE - Research Triangle Park NC
International Classification:
A61K 31/4535, A61K 31/453, A61P 25/06, A61P 37/02, A61P 37/06, A61P 19/02, A61P 37/08, A61P 31/12, A61P 1/12, A61P 25/18, A61P 25/24, A61P 11/14, A61P 25/30, A61P 9/12, A61P 3/04, A61P 25/08, C07D 211/08
US Classification:
514324, 546196, 514320, 546202
Abstract:
Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.