Inventors:
SCOTT T. BRADY - CHICAGO IL, US
LESTER I. BINDER - CHICAGO IL, US
GERARDO ANDRES MORFINI - CHICAGO IL, US
NICHOLAS M. KANAAN - GRAND RAPIDS MI, US
Nichole E. LaPointe - Santa Barbara CA, US
Assignee:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS - URBANA IL
International Classification:
A61K 38/10, A61P 25/28, C12Q 1/02
Abstract:
The present invention is a composition and method for the prevention and treatment of a tauopathy. The composition of the invention includes N-terminal amino acid residues of the tau protein, which have been identified as being involved in toxic activation of a PP1/GSK3 signaling cascade and inhibition of fast axonal transport in human tauopathies.