Inventors:
David Barnes - Waban MA, US
Scott Louis Cohen - Peabody MA, US
Jiping Fu - Lafayette CA, US
Lei Shu - Woburn MA, US
Rui Zheng - Waltham MA, US
International Classification:
C07D 409/04, C07D 413/04, C07D 413/14, A61K 31/496, A61K 31/5377, A61K 31/553, A61K 31/422, A61K 31/506, A61K 45/06, C07D 417/14, A61K 31/541, C07D 409/14, A61K 31/4535
US Classification:
5142308, 544379, 544364, 544146, 546213, 548231, 544295, 544121, 51425213, 51425311, 514326, 514376, 51425218, 5142358, 544 586, 540544, 540524, 5142102, 5142278, 51421115
Abstract:
The present invention provides a compound of formula I:a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.