Inventors:
Scott K. Dessain - Wynnewood PA, US
Sharad P. Adekar - Secane PA, US
Assignee:
THOMAS JEFFERSON UNIVERSITY - Philadelphia PA
International Classification:
A61K 39/40, C12N 5/12, C07K 16/00, C12P 21/08, C07H 21/00, C40B 50/06, C40B 40/10, A61P 31/04, A61P 25/00
US Classification:
4241501, 435326, 5303881, 435 7021, 5303871, 5303873, 536 2353, 506 26, 506 18, 4241671
Abstract:
This invention relates to a novel hybridoma strategy that uses CD27+ B cells cultured in vitro to induce IgM to IgG class switch prior to fusion with a fusion partner. Hybridomas resulting from the fusion between CD27+ B cells and a fusion partner cell line and antibodies secreted from the hybridomas are included in the invention.