DR. SCOTT EDWARD POTENTA, MD, PHD
Radiology at Fruit St, Boston, MA

2010011, May 13, 2010

Jan 31, 2006

11/883260

Douglas B. Weibel - Arlington MA, US
Andrew Lee - Somerville MA, US
Scott Potenta - Boston MA, US
Adam Siegel - Cambridge MA, US
Maarten Kruithof - Delft, NL
George M. Whitesides - Newton MA, US

President and Fellows of Harvard college - Cambridge MA

G05D 7/00, F16K 3/24, F16K 31/02, F16K 31/50

137 1, 137 14, 137329, 137264

A microfluidic valve assembly includes a structure defining a microfluidic fluid path and an actuator that can be moved between different positions controlling flow through the channel. In one embodiment, the actuator can be threaded into at least a portion of the structure, and can be moved rotationally between a first position, causing relatively greater constriction of a microfluidic fluid path, and a second position causing relatively lesser constriction of the fluid path. Actuating the actuator, e.g., by rotation, can deform material between the valve and the fluid path, thereby constricting at least a portion of the underlying fluid path and regulating the flow of a fluid in the fluid path. In another aspect, the invention provides a reservoir into which fluid can be placed and from which fluid can be introduced into a microfluidic system. In one embodiment, the reservoir is expandable and thereby able to store fluid under pressure for delivery to a microfluidic system.