DR. SCOTT D. BODEN, M.D.
Medical Practice at Executive Park South, Atlanta, GA

6444803, Sep 3, 2002

Nov 27, 2000

09/721975

Gregory A. Hair - Atlanta GA
Scott D. Boden - Atlanta GA

Emory University - Atlanta GA

C07H 2104

536 235, 536 2431

The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising nucleotide sequences that encode LMP, as well as host cells comprising those vectors. Moreover, the present invention relates to methods of inducing bone formation by transfecting osteogenic precursor cells with an isolated nucleic acid molecule comprising a nucleotide sequence encoding LIM mineralization protein. The transfection may occur ex vivo or in vivo by direct injection of virus or naked plasmid DNA. In a particular embodiment, the invention provides a method of fusing a spine by transfecting osteogenic precursor cells with an isolated nucleic acid molecule having a nucleotide sequence encoding LIM mineralization protein, admixing the transfected a osteogenic precursor cells with a matrix and contacting the matrix with the spine. Finally, the invention relates to methods for inducing systemic bone formation by stable transfection of host cells with the vectors of the invention.

6521750, Feb 18, 2003

Nov 9, 2001

09/986621

Gregory A. Hair - Atlanta GA 30345
Scott D. Boden - Atlanta GA 30345

C07H 2100

536 235, 514441, 530350

The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising nucleotide sequences that encode LMP, as well as host cells comprising those vectors. Moreover, the present invention relates to methods of inducing bone formation by transfecting osteogenic precursor cells with an isolated nucleic acid molecule comprising a nucleotide sequence encoding LIM mineralization protein. The transfection may occur ex vivo or in vivo by direct injection of virus or naked plasmid DNA. In a particular embodiment, the invention provides a method of fusing a spine by transfecting osteogenic precursor cells with an isolated nucleic acid molecule having a nucleotide sequence encoding LIM mineralization protein, admixing the transfected osteogenic precursor cells with a matrix and contacting the matrix with the spine. Finally, the invention relates to methods for inducing systemic bone formation by stable transfection of host cells with the vectors of the invention.

2010026, Oct 21, 2010

Feb 12, 2010

12/705253

Randal R. Betz - Ocean City NJ, US
Scott Boden - Atlanta GA, US
Munish Chandra Gupta - Carmichael CA, US
Michael F. O'Brien - Plano TX, US
Harvinder Sandhu - Greenwich CT, US
Alexis Shelokov - Plano TX, US
Georgiana Shelokov - Dallas TX, US
Daryl R. Sybert - Columbus OH, US
Alexander Vaccaro - Philadelphia PA, US
Guobao Wei - Eatontown NJ, US
Todd M. Boyce - Matawan NJ, US
Robert Cohen - Rockaway NJ, US
Cristy Richards - Matawan NJ, US
Lawrence A. Shimp - Morganville NJ, US

Osteotech, Inc. - Eatontown NJ

A61B 17/00, A61B 17/58

606 79, 606 94

A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.

2003022, Dec 4, 2003

Mar 7, 2003

10/382844

William McKay - Memphis TN, US
Scott Boden - Atlanta GA, US
Sangwook Yoon - Atlanta GA, US

A61K048/00, C12N005/08, C12N015/861, C12N015/867

514/044000, 424/093200, 435/456000, 435/366000

A method of inducing the expression of one or more bone morphogenetic proteins and/or transforming growth factor- proteins in a cell is described. The method includes transfecting a cell with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. The one or more bone morphogenetic proteins can be BMP-2, BMP-4, BMP-6, BMP-7 or combinations thereof. The transforming growth factor- protein can be transforming growth factor-1 protein (TGF-1). Transfection may be accomplished ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. The method can be used to induce bone formation in osseous cells or to stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycyan and/or collagen (e.g., intervertebral disc cells).

5741261, Apr 21, 1998

Jun 25, 1996

8/670351

Peter A. Moskovitz - Washington DC
Scott Boden - Atlanta GA
William F. McKay - Memphis TN
Joseph Moctezuma - Memphis TN

SDGI Holdings, Inc. - Memphis TN

A61B 1756

606 79

Minimally invasive spinal surgical techniques and tools are provided. The methods include separating the iliocostalis lumborum muscle from the anterior leaf of the thoracolumbar fascia to create a channel from the patient's skin to the intertransverse interval. In one embodiment, the method also includes delivering graft material through the channel to the intertransverse interval. A device according to one aspect of the present invention includes a retraction portion having a flattened plate configured to atraumatically retract tissue to create a working space within an endosurgical site and a curved shaft attached to the retraction portion. The shaft includes a bend having a radius of preferably 160 degrees. A gripping portion is attached to the shaft and is configured for manually gripping and manipulating the device.

2010008, Apr 1, 2010

Mar 27, 2009

12/413013

Daryl R. Sybert - New Albany OH, US
Sigurd Berven - SanFrancisco CA, US
Randal R. Betz - Ocean City NJ, US
Oheneba Boachie-Adjei - New York NY, US
Scott Boden - Atlanta GA, US
Michael F. O'Brien - Coral Gables FL, US
Alexis P. Shelokov - Plano TX, US
John M. Winterbottom - Howell NJ, US

A61B 17/84, A61B 17/56

606326, 606 86 R

Bone anchors and related methods for their use are described. The inventive anchor is suitable for placement in bone and for use in orthopedic surgery and dentistry. The bone anchor can be made from a bone/polymer or bone substitute/polymer composite, and can provide a firm and secure base for attaching a fastening device. The bone anchor can be used in various orthopedic and dental procedures including spinal surgery, where normal, cancellous, cortical, diseased or osteoporotic bone is present. The bone anchor can be resorbed and/or replaced with native bone tissue over a period of time. In certain embodiments, the bone anchor is made malleable or flowable and formed in situ or in vivo.

2003000, Jan 9, 2003

May 2, 2002

10/137862

Albert Manrique - Manalapan NJ, US
Jean Edwards - Hillsborough NJ, US
Nelson Scarborough - Andover MA, US
Scott Boden - Atlanta GA, US
Kathy Traianedes - North Brunswick NJ, US
Lawrence Shimp - Morganville NJ, US
James Russell - Little Silver NJ, US

A61F002/28

623/023630, 623/023510, 623/919000

An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.

7722895, May 25, 2010

Feb 23, 2006

11/361026

William F. McKay - Memphis TN, US
Scott D. Boden - Atlanta GA, US
Neil Beals - Memphis TN, US

A61F 2/00, A61F 2/02, A61F 2/28, A61K 38/00, A61K 38/16, A61K 38/17, A61K 38/18, C07K 14/78, C07K 14/51

424423, 514 7, 514 8, 514 12, 514 2, 514801, 424422, 523115, 1061601, 435273, 530356, 606229

Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.

8092823, Jan 10, 2012

Jan 8, 2010

12/684448

William F. McKay - Memphis TN, US
Scott D. Boden - Atlanta GA, US
Neil B. Beals - Memphis TN, US

Warsaw Orthopedic, Inc. - Warsaw IN

A61F 2/00, A61F 2/02, A61F 2/28, A61K 38/00, A61K 38/16, A61K 38/17, A61K 38/18, C07K 14/78, C07K 14/51

424423, 514 7, 514 8, 514 12, 514801, 424422, 523115, 1061601, 435273, 530356, 606229

Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.